INNOVATING FOR PATIENTS Nasdaq TRVN I February 2020 Forward-Looking Statements To the extent that statements contained in this presentation are not descriptions of historical facts regarding Trevena, Inc. (the "Company" or "we"), they are forward-looking statements reflecting management's current beliefs and expectations. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry's actual results, levels of activity, performance, or ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36193 Delaware 19087 (Zip Code) (Stat ...

Trevena, Inc. (OTC:TRVN) Q2 2019 Earnings Conference Call August 7, 2019 8:00 AM ET Company Participants Robert Yoder - Vice President and Chief Business Officer Carrie Bourdow - President and Chief Executive Officer Mark Demitrack - Chief Medical Officer Barry Shin - Chief Financial Officer Conference Call Participants Jason Butler - JMP Securities Douglas Tsao - H.C. Wainwright & Co. Operator Good day, ladies and gentlemen, and welcome to the Trevena Inc., Second Quarter 2019 Earnings Conference Call. At ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36193 Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdictio ...

Trevena, Inc. (OTC:TRVN) Q1 2019 Results Earnings Conference Call May 13, 2019 8:00 AM ET Company Participants Bob Yoder - Chief Business Officer Carrie Bourdow - President and CEO Mark Demitrack - Chief Medical Officer Conference Call Participants Douglas Tsao - H.C. Wainwright Operator Good day, ladies and gentlemen, and welcome to Trevena’s First Quarter 2019 Earnings Conference Call. At this time, all participants are in a listen-only mode. Later, we will conduct a question-and-answer session and inst ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36193 Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdicti ...

Trevena, Inc. (OTC:TRVN) Q4 2018 Results Conference Call March 13, 2019 8:00 AM ET Company Participants Bob Yoder - Chief Business Officer Carrie Bourdow - President and CEO Mark Demitrack - Chief Medical Officer John Hamill - VP, Finance Conference Call Participants Jason Butler - JMP Securities Tom Yip - H.C. Wainwright Operator Good day, ladies and gentlemen, and welcome to the Trevena Incorporated Fourth Quarter and Full Year 2018 Earnings Conference Call. At this time, all participants are in a listen- ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10‑K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001‑36193 Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 26‑1469215 (State or Other Juri ...