On Thursday, Tyra Biosciences, Inc. TYRA released clinical proof-of-concept data for TYRA-300 in patients with metastatic urothelial (mUC) cancer from its ongoing SURF301 Phase 1/2 study. These data will be presented at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. TYRA-300 is a potential first-in-class, investigational, oral, FGFR3-selective inhibitor designed to avoid the toxicities associated with the inhibition of FGFR1, FGFR2, and FGFR4 while being agnostic for the FGFR3 ga ...

CARLSBAD, Calif., Oct. 23, 2024 /PRNewswire/ -- Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology, today announced that it will host a conference call and webcast on October 25, 2024 at 8:00 am ET to share interim clinical results of TYRA-300 from the SURF301 Phase 1/2 study in metastatic urothelial cancer (mUC). These data will be presente ...

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BofA Securities has upgraded Tyra Biosciences TYRA, a clinical-stage biotechnology company focused on developing next-generation precision medicines. The company's initial focus is on improving small molecule drug discovery and development in targeted oncology and genetically defined conditions. The company has a pipeline of four preclinical candidates. In July, Tyra Biosciences announced preclinical proof-of-concept results with TYRA-300 in hypochondroplasia (HCH), the most common form of dwarfism. TYRA-30 ...

-Dr. Warner brings over twenty years of proven clinical development leadership to TYRA having successfully led global development and secured approvals for medicines across oncology and skeletal disease- CARLSBAD, Calif., Sept. 10, 2024 /PRNewswire/ -- Tyra Biosciences, Inc. (Nasdaq: TYRA), a clinical-stage biotechnology company focused on developing next-generation precision medicines that target large opportunities in Fibroblast Growth Factor Receptor (FGFR) biology, announced today the appointment of Dou ...

Tyra Biosciences, Inc. (TYRA) closed the last trading session at $20.59, gaining 2.5% over the past four weeks, but there could be plenty of upside left in the stock if short-term price targets set by Wall Street analysts are any guide. The mean price target of $26.33 indicates a 27.9% upside potential. The average comprises six short-term price targets ranging from a low of $22 to a high of $33, with a standard deviation of $3.78. While the lowest estimate indicates an increase of 6.9% from the current pri ...

- SURF301 Ph1 initial results and ACH IND submission expected in 2H24 - - Reported preclinical proof-of-concept with TYRA-300 in HCH, demonstrating increases in long bone length and binding against the HCH altered protein - - IND cleared for TYRA-430, an FGFR4/3 biased inhibitor for HCC - - Announced Chief Medical Officer transition plan; search for an external candidate underway with guidance from Science & Technology (S&T) Committee of the Board, including recent additions Dr. Susan Moran and Dr. S. Micha ...

Core Insights - Tyra Biosciences, Inc. announced preclinical proof-of-concept results for TYRA-300, an investigational oral FGFR3 selective inhibitor, in hypochondroplasia (HCH) at the 6th Annual Achondroplasia & Skeletal Dysplasia Research Conference [1][2] Company Overview - Tyra Biosciences is a clinical-stage biotechnology company focused on developing next-generation precision medicines targeting FGFR biology, utilizing its in-house precision medicine platform, SNÅP, for rapid drug design [4] - The company is based in Carlsbad, California, and aims to address large opportunities in targeted oncology and genetically defined conditions [4] Product Development - TYRA-300 has shown promising preclinical results in increasing long bone length and improving growth plate function in a hypochondroplasia mouse model [6][7] - The drug targets the FGFR3 gene, which is commonly mutated in HCH, with no current approved therapeutic options available [6] - The company plans to submit an Investigational New Drug (IND) application in the second half of 2024 to initiate a Phase 2 clinical study in pediatric achondroplasia [2][7] Clinical Study Insights - In preclinical studies, TYRA-300 demonstrated significant increases in the length of various bones in FGFR3 mutated mice, including femur (3.70%), tibia (3.75%), humerus (3.22%), and ulna (5.03%) [9] - The drug also increased the size of the foramen magnum by 5.88% in the same model [9] - TYRA-300 is currently being evaluated in a multicenter, open-label Phase 1/2 clinical study for advanced solid tumors, aiming to determine the recommended Phase 2 dose and evaluate preliminary antitumor activity [7]

Core Viewpoint - Tyra Biosciences, Inc. (TYRA) has been upgraded to a Zacks Rank 2 (Buy), indicating a positive outlook on its earnings estimates and potential stock price increase [1][2][3]. Earnings Estimates and Rating Upgrade - The recent upgrade reflects an upward trend in earnings estimates, which is a significant factor influencing stock prices [1][2]. - Over the past three months, the Zacks Consensus Estimate for Tyra Biosciences has increased by 12.6% [5]. - The upgrade positions Tyra Biosciences in the top 20% of Zacks-covered stocks based on estimate revisions, suggesting potential for stock price appreciation in the near term [15]. Zacks Rating System - The Zacks Rank system classifies stocks into five groups based on earnings estimates, with Zacks Rank 1 (Strong Buy) stocks historically generating an average annual return of +25% since 1988 [4]. - The Zacks rating system maintains a balanced distribution of 'buy' and 'sell' ratings, ensuring that only the top 20% of stocks are rated favorably, which indicates superior earnings estimate revisions [10]. Earnings Outlook - For the fiscal year ending December 2024, Tyra Biosciences is expected to report earnings of -$1.71 per share, reflecting a change of -5.6% from the previous year [9].

TD Cowen's 5th Annual Oncology Innovation Summit: Insights for ASCO & EHA, May 28-29, 2024: Todd Harris, CEO of TYRA, will participate in a fireside chat on Tuesday, May 28, 2024, at 1:00 pm ET. Jefferies Global Healthcare Conference, June 5-6, 2024: TYRA management will participate in one- on-one meetings with investors during the conference. 45th Annual Goldman Sachs Global Healthcare Conference, June 10-13, 2024: Todd Harris, CEO of TYRA, will present on Wednesday, June 12, 2024, at 8:40 am ET. TYRA mana ...