Exhibit 99.3 XORTX THERAPEUTICS INC. ANNUAL INFORMATION FORM FOR THE FISCAL YEAR ENDED DECEMBER 31, 2022 MARCH 31, 2023 TABLE OF CONTENTS Page REFERENCE INFORMATION 1 CAUTION REGARDING FORWARD-LOOKING STATEMENTS 1 CORPORATE STRUCTURE 5 GENERAL DEVELOPMENT OF THE BUSINESS 6 DESCRIPTION OF THE BUSINESS 13 RISK FACTORS 15 ...