Financial Performance - Total revenue for the three months ended September 30, 2024 was 180.9million,comparedto136.1 million in the same period in 2023, representing a 32.9% increase[165] - Net losses for the three months ended September 30, 2024 were 75.8million,comparedto53.4 million in the same period in 2023[165] - Adjusted EBITDA for the three months ended September 30, 2024 was (21.8)million,comparedto(36.2) million in the same period in 2023[165] - Total net revenue increased from 136.1millionto180.9 million for the three months ended September 30, 2024 compared to the same period in 2023, a 33% increase[202] - Adjusted EBITDA improved to (96.9)millionfortheninemonthsendedSeptember30,2024,comparedto(119.1) million in the same period in 2023[234] - The company had an accumulated deficit of 2.1billionasofSeptember30,2024,withcash,cashequivalents,andrestrictedcashtotaling388.9 million[235][237] - Net cash used in operating activities for the nine months ended September 30, 2024 was 149.8million,drivenbyanetlossof692.8 million[247][248] - Cash used in investing activities for the nine months ended September 30, 2024 was 122.4million,includinga95.2 million investment in a joint venture[250] - Cash provided by financing activities for the nine months ended September 30, 2024 was 494.5million,primarilyfromIPOproceedsandSeriesG−5PreferredStockissuance[252]RevenueGrowthandBreakdown−Genomicsrevenueincreasedfrom96.8 million to 116.4millionforthethreemonthsendedSeptember30,2024comparedtothesameperiodin2023,a2039.2 million to 64.5millionforthethreemonthsendedSeptember30,2024comparedtothesameperiodin2023,a6460.5 million (22%) for the nine months ended September 30, 2024, primarily due to a rise in oncology NGS tests from 159,400 to 198,200[217] - Data and services revenue increased by 48.1million(4243.4 million from Insights products and new customer adoption[218] - Total net revenue increased by 108.6million(2860.5 million and Data and services contributing 48.1million[216]ExpensesandCosts−Costofrevenuesincreasedby54.2 million (30%) for the nine months ended September 30, 2024, primarily due to 20.5millioninstock−basedcompensationand16.4 million in material and service costs[220] - Technology research and development expenses increased by 65.2million(9254.4 million in stock-based compensation and 9.4millioninpersonnel−relatedcosts[222]−Selling,generalandadministrativeexpensesincreasedby30.0 million (42%) in Q3 2024, primarily due to 12.6millioninstock−basedcompensationand7.9 million in personnel-related costs[210] - Research and development expenses increased by 53.4million(81119.7 million for the nine months ended September 30, 2024, driven by 44.8millioninstock−basedcompensation,2.2 million in validation fees, and 5.3millioninpersonnelcosts[223]−Selling,general,andadministrativeexpensesroseby432.4 million (204%) to 644.1million,primarilydueto389.6 million in stock-based compensation and increases in personnel, software, and cloud storage costs[224] - Stock-based compensation expense recognized during the nine months ended September 30, 2024 was 509.4million[258]InvestmentsandFinancing−ThecompanycompleteditsIPOonJune17,2024,issuing11,100,000sharesofClassAcommonstockat37.00 per share, with net proceeds of 382.0million[168]−ThecompanyenteredintoaSecuritiesPurchaseAgreementtoacquireAmbryGeneticsCorporationfor375.0 million in cash and 4,843,136 shares of Class A common stock[166] - The company secured a 100millionseniorsecuredrevolvingcreditfacilityand200.0 million in additional term loans to fund the Ambry Genetics acquisition[167] - Net proceeds from the IPO in June 2024 were 382.0million,andthecompanyraised200.0 million in a private placement in April 2024[237] - Term Loan Facility increased to 260millionaftertwoamendments,withinterestratesadjustedby25basispointsand7.25250 million, with principal reductions based on Google Cloud Platform usage[243][244] Partnerships and Commitments - AstraZeneca committed to spend a minimum of 220milliononthecompany′sproductsandservicesthroughDecember31,2028,withpotentialtoincreaseto320 million[174] - GlaxoSmithKline committed to spend a minimum of 180milliononthecompany′sproductsandservicesthroughDecember31,2027,withpotentialforanadditional120 million[176] - Recursion Pharmaceuticals agreed to pay up to 160millioninlicensefeesoverfiveyearsforaccesstothecompany′sproprietarydatabaseandservices[177]ProductandServiceOfferings−Thecompany′sGenomicsproductlineleveragesnext−generationsequencingandothermolecularpathologytestingtogeneratestructured,de−identifieddataforcommercialization[164]−Thecompany′sofferingshavebeenusedbymorethan7,000physiciansandover200biotechcompanies,including19ofthe20largestpublicpharmaceuticalcompaniesbasedon2023revenue[182]−ThenumberofoncologyNGStestsincreasedfromapproximately55,700testsforthethreemonthsendedSeptember30,2023toapproximately69,000testsforthethreemonthsendedSeptember30,2024[203]−Dataandservicesrevenueincreasedby23.3 million in Q3 2024, driven by higher demand for Insights products and growth from existing and new customers[204] Interest and Other Financial Metrics - Interest income increased by 3.3million(2231.4 million (11%) in Q3 2024, primarily due to compounding interest on the Amended Note[212] - Other (expense) income, net decreased by 13.8million(−60445.6 million increase in expense related to the change in fair value of warrant liability[213] - Interest income increased by 1.7million(297.5 million, driven by higher cash on hand as of September 30, 2024[225] - Interest expense rose by 7.0million(2140.3 million, primarily due to compounding interest on debt and additional borrowings[225] - Other (expense) income, net, decreased by 25.7million(−325(17.8) million, driven by a 50.4millionincreaseinwarrantliabilityfairvalueexpense[226]−Lossesfromequitymethodinvestmentsincreasedby1.4 million (462%) to 1.7million,duetolossesfromajointventureenteredintoinJuly2024[228]ReimbursementandTestingMetrics−AsofDecember31,2023,thecompanyhadreceivedpaymentonapproximately50916 and 1,452fortheyearsendedDecember31,2022and2023,respectively[184]RiskFactors−Companyisexposedtointerestrateriskandforeigncurrencyrisk,withnomaterialimpactfromahypothetical10459.1 million and $594.1 million for the years ending December 31, 2024 and 2025, respectively[242]