Revenue Performance - Fourth-quarter revenue was 1.00billion,adecreaseof1.11.01 billion in Q4 2023[2] - Full-year revenue decreased by 1.9% to 4.05billionfrom4.13 billion in 2023[16] - The Manufacturing segment's revenue increased by 1.6% to 194.9millioninQ42024,withorganicrevenuegrowthof2.1603.3 million in Q4 2024, with organic revenue decline of 3.5%[12] - The RMS segment's revenue for 2024 was 829.4million,anincreaseof4.7792.3 million in 2023[19] - Total revenue for the three months ended December 28, 2024, was 1,002,549,000,adecreaseof1.41,013,476,000 for the same period in 2023[34] - Service revenue for the twelve months ended December 28, 2024, was 3,304,138,000,downfrom3,440,019,000 in 2023, reflecting a decline of 4.0%[34] - Reported revenue growth for the three months ended December 28, 2024, was a decline of 1.1%, with the RMS segment growing by 4.3% and the DSA segment declining by 3.6%[46] - For the twelve months ended December 28, 2024, reported revenue growth was a decline of 1.9%, with the RMS segment growing by 4.7% and the DSA segment declining by 6.3%[46] - Non-GAAP revenue growth, organic, for the three months ended December 28, 2024, was a decline of 1.8%, with the RMS segment at a decline of 0.4% and the DSA segment at a decline of 3.5%[46] Earnings and Losses - GAAP loss per share for Q4 2024 was (4.22),adecreasefromearningsof3.62 per share in Q4 2023[6] - Non-GAAP earnings per share for Q4 2024 were 2.66,anincreaseof8.12.46 in Q4 2023[7] - The company reported a net loss of 213,747,000forthethreemonthsendedDecember28,2024,comparedtoanetincomeof188,952,000 for the same period in 2023[34] - Basic earnings per share for the three months ended December 28, 2024, was (4.22),comparedto3.65 for the same period in 2023[34] - For the three months ended December 28, 2024, Charles River Laboratories reported a net loss of 215.7millioncomparedtoanetincomeof187.1 million for the same period in 2023[43] - Non-GAAP net income for the three months ended December 28, 2024, was 136.6million,upfrom127.2 million in the prior year, reflecting a 1.1% increase[43] Financial Guidance and Projections - The company plans to repurchase approximately 350millionincommonstockin2025[1]−2025revenueguidanceindicatesadecreaseof7.09.10 and 9.60[23]OperationalChallengesandFutureOutlook−ThecompanyexpectstofacechallengesrelatedtoNHPsupplyconstraintsandongoinginvestigationsbytheU.S.government,whichmayimpactfuturefinancialperformance[29]−Futurerevenuetrendsareanticipatedtobeinfluencedbyclientdemandfordrugdiscoveryanddevelopmentproductsandservices[29]−Thecompanycontinuestoassessthepotentialvalueofreportingnon−GAAPresultsconsistentwithapplicablerulesandregulations[46]AssetandLiabilityChanges−Totalassetsdecreasedfrom8,195,001 thousand as of December 30, 2023, to 7,528,345thousandasofDecember28,2024,representingadeclineofapproximately8.14,536,003 thousand as of December 30, 2023, to 4,020,267thousandasofDecember28,2024,areductionofapproximately11.4734,577 thousand for the twelve months ended December 28, 2024, compared to 683,898thousandinthepreviousyear,reflectingagrowthof7.4232,967 thousand, down from 318,528thousandin2023,indicatingadecreaseof26.9205,570 thousand from 284,480thousand,adeclineof27.7215,000,000 during the three months ended December 28, 2024[34] - The company reported a goodwill impairment of 215,000thousandforthetwelvemonthsendedDecember28,2024,whichwasnotpresentinthepreviousyear[37]−Thecompanyincurreda27 million inventory charge related to non-human primate inventory issues[40] - The company reported a severance cost of 12.7millionduringthequarter[39]OperatingIncomeandExpenses−OperatingincomeforthetwelvemonthsendedDecember28,2024,was227,347,000, a significant decrease from 617,261,000in2023[34]−Operatingincome(loss)was(167.7) million, with a significant goodwill impairment charge of 215.0millionrecognized[39][40]−Non−GAAPoperatingincomeasapercentageofrevenuewas19.9102.1 million, indicating continued investment in long-term assets[39] Legal and Environmental Issues - Third-party legal costs related to environmental litigation and government investigations impacted financial results[40] - The company experienced a reduction in long-range financial outlook for the Biologics Solutions reporting unit due to loss of key customers[40]