Financial Performance - Coya Therapeutics reported a net loss of 14.9millionfortheyearendedDecember31,2024,comparedtoanetlossof8.0 million for the year ended December 31, 2023, representing an increase of 86.25%[13] - Net loss for 2024 was 14,880,787,comparedtoanetlossof7,987,836 in 2023, reflecting an increase in losses of approximately 86%[26] - Net loss per share increased to 0.98in2024from0.79 in 2023, indicating a deterioration in per-share performance[26] - The company reported a pre-tax loss of 15,601,074in2024,comparedtoapre−taxlossof7,263,984 in 2023, indicating a worsening of about 115%[26] Expenses - Research and development (R&D) expenses increased to 11.9millioninFY2024from5.5 million in FY 2023, primarily due to a 5.0millionriseinpreclinicalexpenses[11]−Generalandadministrativeexpensesroseto8.9 million in FY 2024 from 7.8millioninFY2023,anincreaseofapproximately14.120,803,772 in 2024, up from 13,905,555in2023,markinganincreaseofabout502,663,539 in 2024 from 872,248in2023,representinganincreaseofapproximately20538.3 million, up from 32.6millionasofDecember31,2023,indicatingagrowthof17.538,339,762, up from 32,626,768attheendof2023,showinganincreaseofabout1716,026,816 in 2024, down from 38,425,063in2023,adecreaseofapproximately5844.3 million as of December 31, 2024, compared to 41.3millionasofDecember31,2023[24]RevenueandCollaboration−Collaborationrevenuedecreasedto3,554,061 in 2024 from 6,002,206in2023,representingadeclineofapproximately417,500,000 in 2024, compared to a negative 7,500,000in2023,indicatingasignificantchangeincashflowdynamics[28]StrategicInitiatives−Coyaraised10.0 million in a private placement of 1.38 million shares of common stock, primarily from existing institutional shareholders[4] - The company received a strategic investment of $5.0 million from the Alzheimer's Drug Discovery Foundation to support the development of COYA 302 for Frontotemporal Dementia[4] - Coya is on track to initiate a randomized, double-blind controlled Phase 2b trial in patients with Amyotrophic Lateral Sclerosis (ALS) upon IND acceptance[6] - The company plans to submit additional nonclinical data to support the start of the COYA-302 Phase 2 trial in ALS in Q2 2025[9] - The company is expected to publish ALS biomarker data and additional clinical data in the second half of 2025, which may provide insights into the role of inflammation in neurodegenerative diseases[9]