Summary of Coia Therapeutics Inc. Presentation Company Overview - **Company**: Coia Therapeutics Inc. - **Focus**: Development of therapies for neurodegenerative diseases such as ALS, frontotemporal dementia, Alzheimer's disease, and Parkinson's disease [4][6][10]. Core Points and Arguments - **Vision**: To improve the quality of life for patients with neurodegenerative diseases, shifting the narrative from their illness to their life stories [4]. - **Target Diseases**: - **ALS**: High unmet need with few treatment options; patients typically have a life expectancy of 3-4 years post-diagnosis [5]. - **Frontotemporal Dementia**: No FDA-approved therapies available [5]. - **Alzheimer's and Parkinson's Diseases**: Significant societal impact, affecting both patients and caregivers [6]. - **Scientific Approach**: Focus on neuroinflammation and regulatory T cell dysfunction as a mechanism to potentially halt disease progression [6][13]. - **Pipeline**: - **COIA-302**: A proprietary combination therapy targeting ALS and other neurodegenerative diseases [16]. - **Combination Strategy**: Utilizes low-dose interleukin-2 and CTLA-4 to enhance Treg function and combat neuroinflammation [16][18]. Financial and Strategic Position - **Partnership**: Strategic collaboration with Dr. Reddy's, valued at over $700 million, providing non-dilutive funding and expertise [8][19]. - **Investor Base**: Strong backing from notable investors including Greenlight Capital and David Einhorn [7]. - **Cash Runway**: Strong financial position with a clean cap table [7]. Clinical Data and Milestones - **Promising Results**: Initial trials show potential to stop progression of ALS, with patients maintaining stable ALSFRS scores over six months [22][23]. - **Upcoming Milestones**: - Submission of data for a Phase 2b study in ALS to the FDA [10]. - Anticipated IND filing for frontotemporal dementia [11]. - Ongoing studies in Alzheimer's disease showing ability to halt cognitive decline [25][26]. Market Potential - **Commercial Opportunity**: High sales potential in orphan diseases like ALS and frontotemporal dementia due to lack of existing therapies, estimated in billions of dollars [13]. - **Regulatory Flexibility**: Orphan disease designation may facilitate faster market entry [6]. Additional Insights - **Combination Therapy Potential**: Research indicates that combining COIA-302 with GLP-1 agonists may enhance efficacy in treating Alzheimer's disease [28][29]. - **External Validation**: Support from the Alzheimer's Drug Discovery Foundation reinforces the credibility of Coia's approach [12]. Conclusion - **Future Outlook**: Coia Therapeutics is positioned for significant advancements in the treatment of neurodegenerative diseases, with multiple key milestones expected in the near future [30].

Financial Data and Key Metrics Changes - COYA Therapeutics is publicly traded on NASDAQ under the ticker symbol COYA, with a buy rating and a twelve-month price target of $18 per share [2] - The company anticipates receiving $8.4 million upon IND approval and trial initiation, with a total deal value of $700 million from the partnership with Dr. Reddy's [18][19] Business Line Data and Key Metrics Changes - The primary focus is on neuroinflammation, which is believed to drive the progression of neurodegenerative diseases [4] - COYA's lead asset, COIA-302, is prioritized for ALS, with an IND filing expected by the end of the current quarter and a Phase IIb trial planned [11][12] Market Data and Key Metrics Changes - The company is targeting niche orphan indications like ALS and frontotemporal dementia, while also pursuing mass market indications like Alzheimer's [9] - The current landscape for ALS trials has become more favorable for recruitment due to the withdrawal of other products, which has created enthusiasm among trial sites [20][22] Company Strategy and Development Direction - COYA aims to maximize value by pursuing both niche and broader market opportunities, with a focus on ALS and frontotemporal dementia for regulatory flexibility [10] - The company plans to continue generating data in frontotemporal dementia and Alzheimer's, while also exploring strategic partnerships to enhance its market position [43][45] Management's Comments on Operating Environment and Future Outlook - Management believes that the FDA remains receptive to ALS drug approvals if data supports it, despite recent challenges in the market [21][23] - The company is confident in its approach to neuroinflammation and its potential to address unmet needs in Alzheimer's disease, which is characterized by a lack of effective treatments [30][31] Other Important Information - COYA is developing a regulatory T cell-derived exosome platform aimed at treating systemic and neurodegenerative diseases driven by chronic neuroinflammation, which complements its existing programs [40][42] - The partnership with Dr. Reddy's provides COYA with a strategic advantage and a steady line of sight to non-dilutive funding [45] Q&A Session Summary Question: What is the current focus for COYA Therapeutics? - The immediate focus is on filing for ALS and starting the ALS study, which is expected to be a significant value driver [43] Question: How has the regulatory environment changed for ALS? - There has been no communicated change from the FDA, and recruitment for ALS trials is expected to be easier due to fewer ongoing trials [21][22] Question: What are the expected outcomes for future clinical development? - Relevant outcome measures will include Treg function and cognitive scales, with a focus on stabilizing or improving cognition in Alzheimer's patients [36][38]

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _____ to _____ Commission File Number: 001-41583 Coya Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) | Delaware | 85-4017781 | | --- ...

Coya Therapeutics Reports First Quarter Financial Results and Provides a Corporate Update Houston, TX, May 13, 2025 -- Coya Therapeutics, Inc. (Nasdaq: COYA) ("Coya" or the "Company"), a clinical-stage biotechnology company developing biologics intended to enhance regulatory T cell (Treg) function, provides a corporate update and announces its financial results for the quarter ended March 31, 2025. Recent Corporate Highlights Upcoming Expected Catalysts for 2025 • Announced positive interim results of an in ...

Milan, Italy, May 8, 2025 – Sibylla Biotech today announced the appointment of Dieter Weinand as Chairman of its Board of Directors. Mr. Weinand is an industry veteran, boasting over 35 years in the pharmaceutical sector, including leading business units and drug commercialization initiatives at global organizations. His background includes serving as President, CEO and Chairman of the Board of Bayer Pharmaceuticals AG. At Sibylla, Mr. Weinand’s profound knowledge will guide the Board as the company advance ...

Another stock in the Medical sector, Doximity (DOCS) , has outperformed the sector so far this year. The stock's year-to-date return is 6.2%. In Doximity's case, the consensus EPS estimate for the current year increased 13.2% over the past three months. The stock currently has a Zacks Rank #2 (Buy). Looking more specifically, Coya Therapeutics, Inc. belongs to the Medical - Biomedical and Genetics industry, a group that includes 508 individual stocks and currently sits at #76 in the Zacks Industry Rank. Thi ...

This article is published by Terry Chrisomalis, who runs the Biotech Analysis Central pharmaceutical service on Seeking Alpha Marketplace. If you like what you read here and would like to subscribe to, I'm currently offering a two-week free trial period for subscribers to take advantage of. My service offers a deep-dive analysis of many pharmaceutical companies. The Biotech Analysis Central SA marketplace is $49 per month, but for those who sign up for the yearly plan will be able to take advantage of a 33. ...

Core Viewpoint - Coya Therapeutics, Inc. (COYA) shows significant upside potential with a mean price target of $16.25, indicating a 144.7% increase from its current price of $6.64 [1] Price Targets and Analyst Estimates - The mean estimate consists of four short-term price targets with a standard deviation of $2.06, suggesting variability among analysts; the lowest estimate of $14 indicates an 110.8% increase, while the highest target is $18, representing a 171.1% increase [2] - A low standard deviation in price targets indicates a high degree of agreement among analysts regarding the stock's price movement direction and magnitude [9] Earnings Estimates and Analyst Consensus - Analysts have shown increasing optimism about COYA's earnings prospects, with a strong consensus in revising EPS estimates higher, which correlates with potential stock price increases [11] - Over the last 30 days, one estimate has increased, leading to a 7.8% rise in the Zacks Consensus Estimate for the current year [12] - COYA holds a Zacks Rank 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks based on earnings estimate factors, indicating strong potential for upside [13]

Core Viewpoint - Coya Therapeutics, Inc. (COYA) has received an upgrade to a Zacks Rank 2 (Buy), indicating a positive outlook on its earnings estimates, which is a significant factor influencing stock prices [1][4]. Earnings Estimates and Revisions - The Zacks rating system is based on the changing earnings picture of a company, specifically tracking the Zacks Consensus Estimate for EPS from sell-side analysts [2]. - Coya Therapeutics is projected to earn -$1.36 per share for the fiscal year ending December 2025, reflecting a year-over-year decline of 38.8% [9]. - Over the past three months, the Zacks Consensus Estimate for Coya has increased by 7.8%, indicating a positive trend in earnings estimates [9]. Impact of Institutional Investors - Changes in a company's future earnings potential, as shown through earnings estimate revisions, are strongly correlated with near-term stock price movements, influenced by institutional investors who adjust their valuations based on these estimates [5][6]. Zacks Rank System - The Zacks Rank system classifies stocks into five groups based on earnings estimates, with Zacks Rank 1 (Strong Buy) stocks historically generating an average annual return of +25% since 1988 [8]. - Coya Therapeutics' upgrade to Zacks Rank 2 places it in the top 20% of Zacks-covered stocks, suggesting a strong potential for market-beating returns in the near term [11].

Core Viewpoint - Coya Therapeutics, Inc. (COYA) shows significant upside potential with a mean price target of $16.25, indicating a 149.6% increase from its current price of $6.51 [1] Price Targets and Analyst Estimates - The mean estimate consists of four short-term price targets with a standard deviation of $2.06, where the lowest estimate of $14 suggests an 115.1% increase, and the highest estimate of $18 indicates a 176.5% increase [2] - A low standard deviation among price targets suggests strong agreement among analysts regarding the stock's price movement direction [9] Earnings Estimates and Analyst Sentiment - Analysts have shown growing optimism regarding COYA's earnings prospects, as indicated by a positive trend in earnings estimate revisions, which correlates with potential stock price movements [11] - The Zacks Consensus Estimate for the current year has increased by 7.8% over the past month, with one estimate rising and no negative revisions [12] Zacks Rank and Investment Potential - COYA holds a Zacks Rank 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks based on earnings estimate factors, indicating strong potential for upside in the near term [13]