诺禾致源(688315) - 2023 Q4 - 年度财报

Dividend Distribution and Share Capital - The company plans to distribute a cash dividend of RMB 0.047 per share, totaling RMB 19,409,822.60, representing 10.90% of the net profit attributable to shareholders[6] - The total share capital of the company is 416,200,000 shares, with 3,225,051 shares deducted from the repurchase account[6] - The company did not issue bonus shares or convert capital reserves into share capital in 2023[6] - The company's cash dividend distribution plan is subject to approval at the shareholders' meeting[6] Financial Performance and Metrics - Revenue for 2023 reached RMB 2,002,107,701.39, a year-on-year increase of 3.97%[25] - Net profit attributable to shareholders of the listed company in 2023 was RMB 178,059,764.27, a slight increase of 0.47% compared to the previous year[25] - Revenue from Hong Kong, Macau, Taiwan, and overseas regions in 2023 was RMB 985,364,200, a year-on-year increase of 22.06%[26] - Basic and diluted earnings per share for 2023 remained stable at RMB 0.44 per share[27] - R&D expenditure as a percentage of revenue decreased to 6.20% in 2023, down 0.71 percentage points from the previous year[26] - Total assets at the end of 2023 were RMB 3,594,420,954.11, an increase of 17.92% compared to the end of 2022[25] - Net cash flow from operating activities in 2023 was RMB 334,197,677.56, an increase of 9.96% compared to the previous year[25] - Revenue in the fourth quarter of 2023 was RMB 573,030,207.55, the highest among all quarters[29] - Net profit attributable to shareholders in the fourth quarter of 2023 was RMB 52,785,463.88, also the highest among all quarters[29] - Non-recurring gains and losses in 2023 amounted to RMB 38,072,422.44, an increase from RMB 23,525,546.84 in 2022[31] - Revenue for 2023 reached RMB 20,021.077 million, a year-on-year increase of 3.97%[36] - Net profit attributable to shareholders was RMB 1,780.598 million, up 0.47% year-on-year[36] - R&D investment totaled RMB 1,241.822 million, accounting for 6.20% of revenue[36] - Revenue for the reporting period reached RMB 20,021.08 million, a year-on-year increase of 3.97%[117] - Net profit attributable to shareholders was RMB 1,780.60 million, up 0.47% year-on-year[117] - Operating cash flow increased by 9.95% to RMB 3,341.98 million[117] - R&D investment accounted for 6.20% of revenue, totaling RMB 1,241.82 million[117] - Overseas revenue from Hong Kong, Macau, Taiwan, and other regions grew by 22.06% to RMB 985.36 million[118] - Sales expenses increased by 14.31% due to expanded overseas market efforts[119] - Financial expenses decreased due to higher interest income and reduced exchange losses[120] - Total assets grew by 17.92% to RMB 35,944.21 million[117] - Shareholders' equity increased by 25.07% to RMB 24,574.58 million[117] - Gene sequencing business revenue reached 1,997,501,624.29 RMB, with a gross margin of 42.79%, a decrease of 1.49 percentage points year-over-year[123] - Life science basic research services revenue was 635,638,550.12 RMB, with a gross margin of 55.48%, an increase of 0.75 percentage points year-over-year[123] - Sequencing platform services revenue grew by 14.05% to 952,578,828.46 RMB, with a gross margin increase of 0.06 percentage points[123] - Gene sequencing data production increased by 43.89% to 22,981.84 TB, with sales up 41.38% and inventory up 27.47%[125] - Direct labor costs for gene sequencing services increased by 3.55% to 149,398,580.29 RMB, accounting for 13.07% of total costs[128] - Direct material costs for sequencing platform services rose by 15.25% to 398,816,181.06 RMB, representing 34.90% of total costs[128] - Medical research and technical services saw a 30.25% increase in direct labor costs to 33,907,311.12 RMB[128] - Sales expenses increased by 14.31% to 379,090,796.48 yuan, while R&D expenses decreased by 1.10% to 124,182,171.31 yuan[139] - Operating cash flow increased by 30.25 million yuan due to higher revenue and customer repayments[140] - Investment cash flow increased by 435.52 million yuan due to increased investment in financial assets[140] - Financing cash flow increased by 334.48 million yuan due to A-share stock issuance[140] - Trading financial assets increased by 332.60% to 826.92 million yuan, accounting for 23.01% of total assets[142] - Overseas assets amounted to 1,167.85 million yuan, representing 32.49% of total assets[143] - Novogene (HK) Company Limited reported revenue of 237.81 million yuan and net profit of 1.17 million yuan[145] - Restricted assets totaled 13.11 million yuan, primarily due to performance bonds and deposits[146] - Total investment in 2023 was RMB 12,732,072.02, a decrease of 49.99% compared to the previous year's RMB 25,457,831.75[149] - The company invested USD 222,042 in May 2023, USD 229,698 in August 2023, and USD 114,849 in December 2023 in the Illumina fund[149] - Invested RMB 3,000,000 in Suzhou Jinsha Lake Runpu Venture Capital Partnership in August 2023[149] - Invested SGD 1,087,800 in NOVOGENE N HEALTH (THAILAND) COMPANY LIMITED in July 2023, classified as a long-term equity investment[150] - Held RMB 150 million in transferable large-denomination certificates of deposit as of December 31, 2023, with accrued interest of RMB 9,052,693.33[151] - The fair value of bank wealth management products at the end of the period was RMB 826,916,983.34[154] - The fair value of other equity instrument investments at the end of the period was RMB 32,344,900.00[154] - The fair value of other non-current financial assets at the end of the period was RMB 157,420,507.07[154] - Total fair value of financial assets at the end of the period was RMB 1,017,753,110.41[154] - The company's subsidiary, Tianjin Novogene Bioinformatics Technology Co., Ltd., reported a net loss of RMB 3,045,140 in 2023[158] Market and Industry Trends - Global gene sequencing market is projected to grow from USD 13.518 billion in 2020 to USD 37.721 billion by 2026, with a CAGR of 19.1%[36] - The global gene sequencing market size reached $13.518 billion in 2020 and is expected to grow to$37.721 billion by 2026, with a CAGR of 19.1% from 2021 to 2026[166] - The gene sequencing services market accounted for 51.74% of the total industry in 2020, with a market size of $6.994 billion, and is projected to reach$21.066 billion by 2026, with a CAGR of 20.7%[166] - China's gene sequencing market size reached $1.339 billion in 2020 and is expected to grow to$4.235 billion by 2026, with a CAGR of 21.6%, higher than the global market growth rate[166] - The gene sequencing industry is divided into upstream (sequencing equipment and reagent manufacturers), midstream (sequencing service providers), and downstream (end-users including universities, research institutions, and individuals)[167][168][170] - Major upstream players include Illumina, Thermo Fisher, MGI (BGI Genomics), Pacific Biosciences, and Oxford Nanopore Technologies, with high market concentration due to the dominance of high-throughput sequencing technology[167] - Midstream service providers are categorized into two types: those serving basic research (e.g., Novogene, Biomarker) and those focusing on clinical applications (e.g., Burning Rock, Genetron Health)[168] - The company entered the upstream high-throughput sequencing equipment and reagent manufacturing field in 2013 through the acquisition of Complete Genomics and has since launched a series of localized sequencing instruments and reagent products[167] - The development of gene sequencing technology has gone through three stages: Sanger sequencing (high accuracy but low throughput), high-throughput sequencing (mainstream technology with high accuracy and throughput), and single-molecule sequencing (long read length but lower accuracy)[165] - The integration of genomics, proteomics, and metabolomics technologies, combined with bioinformatics analysis capabilities, enables the company to provide comprehensive solutions for scientific research[169] - The company's midstream services focus on reducing sequencing costs, shortening sequencing cycles, and lowering the threshold for gene sequencing applications, driving the widespread adoption of sequencing technology in both basic research and commercial applications[169] - Second-generation sequencing technology will remain the mainstream for a long time due to its high throughput, accuracy, and relatively low cost[171] - Multi-omics research technology is a key future tool for life sciences and medical research, integrating genomics, transcriptomics, proteomics, and metabolomics[172] - The gene sequencing service industry is moving towards centralized outsourcing, with large service providers increasing their market share[172] - The clinical application of gene sequencing is rapidly growing, particularly in NIPT, genetic disease diagnosis, and tumor diagnosis and treatment[173] Corporate Governance and Compliance - The company has no significant risks affecting its operations during the reporting period[4] - The company's financial report was audited by Ernst & Young (Special General Partnership) with a standard unqualified opinion[5] - The company's future plans and strategies are forward-looking statements and do not constitute a commitment to investors[8] - The company has no non-operational fund occupation by controlling shareholders or related parties[9] - The company has no violations of decision-making procedures for external guarantees[9] - The company's board of directors unanimously approved the annual report, ensuring its authenticity, accuracy, and completeness[4] - The company strictly adheres to the requirements of the "Company Law," "Securities Law," and other relevant laws and regulations, continuously improving its corporate governance structure and internal management and control systems[183] - The company ensures that all shareholders, especially minority shareholders, can fully exercise their voting rights by combining on-site and online voting methods during shareholder meetings[183] - The company has established four specialized committees under the board of directors—strategy, audit, compensation and evaluation, and nomination—to provide scientific decision-making support[184] Research and Development - The company utilizes advanced sequencing technologies such as Ribo-seq, ATAC-seq, and ChIP-seq for genomic research[16][17] - The company is involved in non-invasive prenatal testing (NIPT) through the analysis of cell-free RNA (cfRNA) in maternal blood[17] - The company employs cutting-edge techniques like CUT&Tag for studying DNA-protein interactions[17] - The company opened new laboratories in Munich, Germany, and Japan, enhancing its global localization strategy[37] - The company developed a multi-omics integrated analysis platform, offering unified analysis services for various omics data[37] - The company launched an automated mass spectrometry multi-omics sample pre-processing system, integrating 17 precision devices for 24/7 intelligent production[40] - The company expanded its clinical application of gene sequencing, with its mutation detection kit being adopted by dozens of core hospitals[40] - The company strengthened its NGS technology application in genetic diseases, collaborating with over 10 top-tier hospitals and hundreds of third-party medical institutions[41] - The company's independently developed pathogen metagenomic high-throughput detection product (mNGS) PD-seq series has successfully established research collaborations with several top-tier hospitals[42] - The company's "Automated Sample Preparation System" (Model: NovoEMD LPS-32) was officially approved by the Tianjin Medical Products Administration on April 10, 2023, achieving automation in NGS library preparation[42] - The company has established a globally leading gene sequencing platform with a large throughput scale, and has published or been mentioned in a total of 22,852 SCI articles by 2023, with a cumulative impact factor of nearly 148,277.93[43] - The company holds 66 invention patents and 356 software copyrights[43] - The company has built a global technical service network, covering approximately 90 countries and regions across six continents, and serves nearly 7,300 customers[44] - The company's third-class medical device "Human EGFR, KRAS, BRAF, PIK3CA, ALK, ROS1 Gene Mutation Detection Kit (Semiconductor Sequencing Method)" was approved in August 2018, becoming one of the first NGS-based tumor gene detection kits approved in China[44] - The company's products include life science basic research services, medical research and technical services, and library construction and sequencing platform services[45] - The company has developed an automated extraction process for relatively standardized samples and has accumulated over a hundred personalized extraction methods for non-standard samples[51] - The company has achieved automation in standard library construction and has rich experience in differential processing of non-standard library construction processes[51] - The company focuses on improving automation levels at each stage to reduce manual errors and improve sequencing efficiency and quality stability[52] - The company actively promotes digital marketing through online channels to enhance product awareness and customer interaction[53] - The company provides full-process, one-on-one professional services to establish long-term customer relationships[54] - The company has a high-quality technical and management team of over 1,000 experts and talents in fields such as molecular biology, medicine, clinical laboratory science, mathematics, physics, agronomy, computer science, and informatics[61] - The company has co-authored or been mentioned in 22,852 SCI articles with a cumulative impact factor of nearly 148,277.93, and holds 66 invention patents and 356 software copyrights[61] - The company serves nearly 7,300 customers globally, including 4,200 research institutes and universities, 680 hospitals, and 2,400 pharmaceutical and agricultural enterprises, covering approximately 90 countries and regions across six continents[61] - The company established a local laboratory in Germany in 2023 and plans to establish another in Japan in early 2024, with further plans to build and expand laboratories in more regions to better serve clients[62] - The company has developed a comprehensive multi-omics service system, including genomics, variantomics, transcriptomics, epigenomics, microbiomics, spatial transcriptomics, single-cell sequencing, mass spectrometry, and genotyping technologies[62] - The company has served global clients in publishing over 210 single-cell related research papers by 2023, offering a full range of single-cell sequencing services including tissue sample dissociation, cell sorting, microfluidic droplet-based single-cell capture, and micro-well-based single-cell capture[63] - The company has achieved DNA extraction success rates of 96.71%, RNA extraction success rates of 89.37%, and third-generation extraction success rates of 91.30% through optimized extraction methods for various sample types[67] - The company has introduced multiple Illumina NovaSeq X Plus, BGI DNBSEQ-T7, and PacBio Revio sequencing platforms, significantly enhancing sequencing throughput and global delivery capabilities[69] - The company has established a high-performance data center with approximately 92TB of memory, 22.5PB of local storage, and scalable cloud storage up to 100PB, supporting big data analysis and storage needs[69] - The company has developed 320 software copyrights in bioinformatics, providing standardized and efficient bioinformatics analysis solutions for life science researchers[69] - The company has conducted over 130 lean improvement activities globally, enhancing efficiency across various stages from sample collection to sequencing[70] - The company deployed the Falcon II system in key laboratories worldwide, including the UK, US, Tianjin, Guangzhou, and Shanghai, achieving intelligent upgrades in global delivery systems[71] - The company has developed 19 patents and over 40 software copyrights in de novo sequencing technology, with 120 co-authored papers published in international journals, accumulating an impact factor of over 1,225[72] - The company launched the NGP (Novogene Germplasm resource screening panel) and developed over ten commercialized liquid chip products for agricultural breeding, enabling efficient and low-cost molecular breeding[73] - The company upgraded its molecular breeding framework, including a breeding value prediction system with nine models and a precision variety identification architecture with five machine learning algorithms[74] - The company holds 5 patents and 52 software copyrights in transcriptomics and epigenomics sequencing, with 15 papers published in international journals, including top-tier journals like The Plant Cell[75] - The company achieved breakthroughs in ATAC-seq for challenging species and optimized Hi-C library construction, improving sequencing data efficiency to advanced levels[76] - The company obtained 4 patents and over 20 software copyrights in metagenomics sequencing, with 13 papers published in international journals[77] - Introduced more accurate alignment algorithms and scoring models, significantly improving metagenomic data assembly efficiency and alignment quality[78] - Served global customers with over 210 single-cell related research papers published by 2023[78] - Increased the success rate of processing frozen tissue samples to over 90%, expanding the application range of single-cell sequencing technology[79] - Completed over 10,000 single-cell sample sequencing cases in the past 5 years[79] - Established FFPE sample processing technology, enabling single-cell and spatial multi-omics integrated analysis of pathological samples[79] - Developed automated cell annotation tools, significantly improving the efficiency of single-cell data analysis[80] - Obtained 2 invention patents and 21 software copyrights in single-cell sequencing data analysis by 2023[80] - Developed a multi-omics database management platform to assist users in managing massive multi-omics data[81] - Constructed the world's first graphical pan-genome for a forage crop, Pennisetum, in collaboration with Sichuan Agricultural University[82] - Developed a 16s microbial classification unit abundance and host