Day One Biopharmaceuticals pany(DAWN) - 2025 Q4 - Annual Results
2026-02-24 21:00
Financial Performance - As of December 31, 2025, the company reported cash, cash equivalents, and short-term investments of $441.1 million[5]. - OJEMDA net revenue for Q3 2025 was $38.5 million, up from $20.1 million in Q3 2024, representing a 91.5% increase[42]. - Total revenue for the nine months ended September 30, 2025, was $104.5 million, compared to $102.0 million for the same period in 2024, showing a 2.5% increase[42]. - The company reported a net loss of $19.7 million for Q3 2025, compared to a net income of $37.0 million in Q3 2024[42]. - Research and Development expenses for the nine months ended September 30, 2025, were $107.2 million, down from $165.9 million in 2024, a decrease of 35.4%[42]. - Selling, General and Administrative expenses for the nine months ended September 30, 2025, were $86.4 million, slightly up from $85.7 million in 2024[42]. Product Development and Approval - OJEMDA received FDA approval in April 2024 for pediatric patients aged 6 months and older with specific BRAF alterations[4]. - The company plans to advance the Emi-Le program with a path toward registration and has acquired Mersana Therapeutics[5]. - The pivotal Phase 3 trial of tovorafenib in front-line pediatric low-grade glioma (pLGG) is expected to complete enrollment in 1H 2026, with topline data expected mid-2027[31]. - The company plans to complete FIREFLY-2 trial enrollment in the first half of 2026, enabling mid-2027 data readout and potential approval in 2028[43]. - The company anticipates delivering Phase 1 clinical data for Emi-Le by mid-2026 and progressing to later-stage development[43]. - DAY301 is a next-generation antibody-drug conjugate (ADC) targeting PTK7, with Phase 1a data expected in 2H 2026[37]. Market Opportunity and Growth - The company aims to solidify OJEMDA as the second-line standard of care (SOC) in relapsed or refractory pediatric low-grade glioma (pLGG) and expand its market opportunity[5]. - The company anticipates a revenue opportunity exceeding $1 billion across three high unmet need indications[7]. - The number of treatment decisions for relapsed or refractory pediatric low-grade glioma (pLGG) is approximately 1,100 annually, with significant room for market share growth for OJEMDA[14]. - OJEMDA's estimated net product revenues for Q4 2025 are projected to be $52.8 million, reflecting a 37% growth compared to Q3 2025 and a 172% increase from 2024[15]. - The expected net product revenue for OJEMDA in 2026 is estimated to be between $225 million and $250 million, indicating over 50% growth compared to 2025[16]. - OJEMDA has achieved a 60% increase in 2L adoption over the past 12 months, with a growing number of healthcare providers selecting it as their treatment of choice[17]. - The company anticipates a significant increase in prescribing accounts, with 28% sequential growth in accounts treating four or more patients[18]. - OJEMDA's commercial execution is expected to drive strong growth in 2026, supported by favorable payer dynamics and a solidified position as the second-line standard of care[16]. Clinical Data and Efficacy - OJEMDA's median duration of response is reported at 19.4 months, with 77% of patients treatment-free for at least 12 months following 24 months of therapy[12]. - 75% of patients in the Expanded Access Program (EAP) who reached 24 months on OJEMDA continued treatment, demonstrating strong persistency[17]. - The Phase 2 FIREFLY-1 trial reported a 53% overall response rate (ORR) among patients, with 58% completing 26 or more treatment cycles[23]. - Median tumor size change from baseline after the last dose was -51% at 3 months and -55% at 6 months post-treatment[26]. - All 8 patients receiving OJEMDA retreatment were still on therapy at the time of data cutoff, with a median change in tumor size of -38.3%[27]. - In the updated 3-year analysis, 38 patients had RAPNO-defined progressive disease (PD) while on OJEMDA[26]. - No new safety signals were observed in the 3-year update, with 66% of treatment-related adverse events (TRAEs) being grade ≥3[29]. - 77% of 39 patients were treatment-free for at least 12 months, with the median treatment-free interval not yet reached[28]. Intellectual Property - The patent portfolio for OJEMDA includes a composition of matter patent extending to mid-2036, with additional protections potentially extending into the 2040s[20]. Strategic Partnerships - The company is focused on global commercial expansion through partnerships, including a license agreement with Ipsen for OJEMDA outside the U.S.[6]. - The company aims to expand OJEMDA globally, extending its commercial opportunity through collaboration with Ipsen[43].
eXp(EXPI) - 2025 Q4 - Annual Results
2026-02-24 20:59
Exhibit 99.1 eXp World Holdings Reports Q4 and Full-Year 2025 Results BELLINGHAM, Wash. — February 24, 2026 — eXp World Holdings, Inc. (Nasdaq: EXPI) (the "Company," "eXp" or "we"), the holding company for eXp Realty®, FrameVR.io and SUCCESS® Enterprises, today announced financial results for the fourth quarter and fiscal year ended December 31, 2025. "2025 was a defining year for eXp Realty, validating our belief that transparency and agent empowerment are the only sustainable paths forward," said Leo Pare ...
MKS Instruments(MKSI) - 2025 Q4 - Annual Report
2026-02-24 20:31
Revenue Performance - Total net revenues for 2025 were $3,931 million, a 10% increase from $3,586 million in 2024[253] - Semiconductor market revenues increased by $198 million, or 13%, in 2025, driven by higher sales in logic and foundry applications[257] - Electronics and packaging market revenues rose by $189 million, or 20%, in 2025, primarily due to increased sales of chemistry and equipment[259] - Specialty industrial market revenues decreased by $42 million, or 4%, in 2025, mainly due to lower sales to industrial customers[265] - Approximately 81% of total net revenues in 2025 came from international markets, up from 78% in 2024[266] - International net revenues reached $3.2 billion in 2025, up from $2.8 billion in 2024, with a notable $155 million increase in sales to China[303] - Product revenues increased by $312 million (10.0%) to $3.436 billion in 2025, driven by a $206 million increase in the electronics and packaging market and a $146 million increase in the semiconductor market[301] - Service revenues rose by $33 million (7.1%) to $495 million in 2025, primarily due to increased revenues in the semiconductor market[302] Market Segment Analysis - The semiconductor market represented 43% of total net revenues in 2025, compared to 42% in 2024[256] - The electronics and packaging market accounted for 28% of total net revenues in 2025, up from 26% in 2024[259] - The specialty industrial market comprised 29% of total net revenues in 2025, down from 32% in 2024[265] Financial Management - Bad debt expense was immaterial in each period presented, indicating effective credit management despite potential customer payment issues[277] - A valuation allowance of $72 million was decreased in 2025, primarily related to foreign interest and net operating loss carryforwards, indicating improved realizability of deferred tax assets[294] - The company uses derivative instruments for risk management, including foreign exchange forward contracts and interest rate swaps, to mitigate market risks[296] - Changes in market conditions could increase the likelihood of recording impairment charges for goodwill and intangible assets, necessitating ongoing monitoring[293] Expenses and Profitability - Gross profit margin decreased to 46.7% in 2025 from 47.6% in 2024, primarily due to higher duty and tariff costs and unfavorable product mix[305] - Research and development expenses increased by $28 million (10.3%) to $299 million in 2025, mainly due to higher compensation-related costs[309] - Selling, general and administrative expenses rose by $50 million (7.4%) to $724 million in 2025, primarily driven by increased compensation-related costs[313] - Interest expense decreased by $65 million (24.7%) to $198 million in 2025, attributed to the issuance of $1.4 billion in Convertible Notes and lower interest rates from loan amendments[319] - Loss on extinguishment of debt was $10 million in 2025, a decrease from $57 million in 2024, due to voluntary prepayments and loan repricing[320] Cash Flow and Financing Activities - Net cash provided by operating activities for 2025 was $645 million, resulting from net income of $295 million, including non-cash charges of $275 million[335] - Net cash used in investing activities for 2025 was $145 million, primarily for capital expenditures of $148 million related to new facility additions in Malaysia and China[337] - Net cash used in financing activities for 2025 was $562 million, including normal quarterly debt payments and voluntary debt prepayments totaling $451 million[338] - The company repurchased approximately 546,000 shares of common stock for a total consideration of $45 million in 2025[341] - The Board of Directors declared a quarterly cash dividend of $0.25 per share to be paid on March 6, 2026, to shareholders of record as of February 23, 2026[343] Debt and Credit Facilities - As of December 31, 2025, the principal outstanding on the Term Loan Facility was $2.9 billion, with a weighted average interest rate of 5.4%[347] - The company made a voluntary prepayment of approximately $1.3 billion on the USD Tranche B loan, reducing the principal from $2.2 billion to $914 million[355] - The company completed a private offering of $1.4 billion in convertible senior notes due 2030, with a coupon rate of 1.25% per annum[356][358] - The company issued €1.0 billion in senior notes due 2034, with an interest rate of 4.250% per annum[367][370] - As of December 31, 2025, the notional value of interest rate swap agreements was $1.9 billion[382] Inventory and Asset Management - Excess and obsolete inventory expense was $45 million, $56 million, and $64 million for 2025, 2024, and 2023, respectively, with 2023 charges partly due to a product line discontinuation[278] - Warranty costs are estimated based on historical repair costs, with obligations ranging from 12 to 36 months, impacting short-term and long-term liabilities[279] - The company has purchase commitments for certain inventory components and other equipment totaling approximately $490 million as of December 31, 2025[389] Taxation - The provision for income taxes for 2025 was $9 million, with an effective tax rate of 2.9%, while 2024 had a benefit of $(10) million with an effective tax rate of (5.7)%[323] - Total gross unrecognized tax benefits as of December 31, 2025, were $95 million, up from $94 million in 2024, mainly due to income tax reserves related to intercompany transactions[325]
Washington Trust(WASH) - 2025 Q4 - Annual Report
2026-02-24 20:29
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K (Mark One) ☒ Annual report pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 for the fiscal year ended December 31, 2025 or ☐ Transition report pursuant to section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from ____________ to ____________ Commission file number: 001-32991 WASHINGTON TRUST BANCORP, INC. (Exact name of registrant as specified in its charter) Rhode Island 05- ...
ZIONS BANCORPORA(ZIONP) - 2025 Q4 - Annual Report
2026-02-24 20:25
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 COMMISSION FILE NUMBER 001-12307 ZIONS BANCORPORATION, NATIONAL ASSOCIATION (Exact name of registrant as specified in its charter) United States of America 87-0189025 (State or other jurisdiction of incorporation or organization) One South Main, Salt Lake City, Utah 84133-1109 (Address of principal ...
ZIONS(ZIONL) - 2025 Q4 - Annual Report
2026-02-24 20:25
OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from __________ to __________ COMMISSION FILE NUMBER 001-12307 ZIONS BANCORPORATION, NATIONAL ASSOCIATION (Exact name of registrant as specified in its charter) United States of America 87-0189025 (State or other jurisdiction of incorporation or organization) One South Main, Salt Lake City, Utah 84133-1109 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ...
Zions Bancorporation(ZION) - 2025 Q4 - Annual Report
2026-02-24 20:25
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from __________ to __________ COMMISSION FILE NUMBER 001-12307 ZIONS BANCORPORATION, NATIONAL ASSOCIATION (Exact name of registrant as specified in its charter) United States of A ...
Gentex(GNTX) - 2025 Q4 - Annual Report
2026-02-24 20:18
Financial Performance - In 2025, the Company's consolidated net sales increased by $221.0 million, or 10% compared to 2024, with core Gentex sales at $2.27 billion, a 2% decline from 2024[144]. - The Company recorded a net income decrease of $19.6 million in 2025, or 5% compared to 2024, mainly due to changes in Other (loss) income[153]. - Adjusted net income attributable to Gentex Corporation for 2025 was $389.7 million, resulting in an adjusted earnings per share of $1.76[166]. Cost and Expenses - Cost of goods sold as a percentage of net sales decreased from 66.7% in 2024 to 65.8% in 2025, resulting in a gross margin improvement of 12.4% year-over-year[146]. - Engineering, research and development expenses increased by $21.8 million, or 12%, from 2024 to 2025, primarily due to the VOXX acquisition[147]. - Selling, general and administrative expenses rose by $56.8 million, or 47%, from 2024 to 2025, largely attributed to the addition of VOXX[148]. - Total operating expenses increased to 15.5% of net sales in 2025, up from 13.5% in 2024, reflecting the impact of the VOXX acquisition and severance expenses[149]. Sales and Revenue Guidance - Automotive net sales without VOXX were $2.22 billion in 2025, a 2% decrease from $2.26 billion in 2024, with a 6% decline in auto-dimming mirror shipments[145]. - VOXX contributed total net sales of $267.2 million for calendar year 2025, included in the Company's financial statements from Q2 2025[144]. - The company estimates top line revenue for 2026 will be between $2.60 billion and $2.70 billion, influenced by light vehicle production forecasts and the VOXX acquisition[181]. - The Company provides revenue guidance for calendar year 2027, estimating revenue will be between $2.75 billion and $2.85 billion, based on light vehicle production forecasts[189]. Cash Flow and Assets - Cash flow from operating activities increased by $88.9 million to $587.1 million in 2025, primarily due to increases in accounts payable and accrued sales incentives[168]. - Cash flow used for investing activities rose to $266.9 million in 2025, driven by increased business acquisitions[169]. - As of December 31, 2025, cash and cash equivalents were $145.6 million, down from $233.3 million in 2024[167]. - Accounts receivable increased by $73.2 million as of December 31, 2025, mainly due to the addition of VOXX sales[173]. Future Projections - Gross margin for 2026 is projected to be between 34.0% and 35.0%, with efforts to offset customer price reductions through operational efficiencies[183]. - Operating expenses for 2026 are expected to be between $410 million and $420 million, reflecting investments in growth initiatives and the full year of VOXX operating expenses[184]. - Capital expenditures for 2026 are anticipated to be between $125 million and $140 million, primarily for production equipment purchases[186]. - The Company estimates depreciation and amortization expense for calendar year 2026 will be between $100 million and $110 million[187]. Market Risks - The Company is exposed to market risks including interest rate fluctuations, commodity price risks, and foreign currency exchange rates[191]. - The Company does not believe that interest rate risk has a material impact on its financial condition or cash flows[192]. - Less than 10% of revenues for the years ended December 31, 2025, 2024, and 2023 were earned in non-U.S. dollar denominated currencies[194]. Business Combinations - The Company accounts for business combinations in accordance with ASC 805, allocating purchase price to tangible and intangible assets based on fair values[202]. - Contingent consideration may be paid for certain acquisitions based on future performance, recorded at fair value at the acquisition date[205]. - The Company does not have significant off-balance sheet arrangements or commitments not recorded in its Consolidated Financial Statements[195]. Share Repurchase Plan - The Company intends to continue its share repurchase plan in 2026 and beyond, depending on market and economic conditions[188].
Chevron(CVX) - 2025 Q4 - Annual Report
2026-02-24 20:03
Reserves and Production - Chevron's proved reserves at year-end 2025 were approximately 10.6 billion barrels of oil-equivalent (BOE), an increase of 8% compared to 2024[29]. - The largest additions to reserves were attributed to the acquisition of Hess Corporation and extensions and discoveries in shale and tight assets in the Permian Basin, along with project approvals in Australia and Guyana[29]. - At December 31, 2025, 43% of Chevron's net proved oil-equivalent reserves were located in the United States, 15% in Australia, and 11% in Kazakhstan[29]. - Total proved reserves of crude oil, condensate, and synthetic oil decreased from 4,777 million barrels in 2023 to 4,369 million barrels in 2025, a decline of approximately 8.5%[30]. - Average worldwide oil-equivalent production is projected to increase by 7% to 10% in 2026 compared to 2025, assuming a Brent crude oil price of $60 per barrel[33]. - Net production of crude oil, natural gas liquids, and natural gas reached 3.7 million barrels per day in 2025, representing a 12% increase from 2024, driven by the acquisition of Hess and record production in the Permian Basin[36]. - The total oil-equivalent production in 2025 included 1,429 thousand barrels per day of crude oil and 7,838 million cubic feet per day of natural gas[37]. - The total consolidated production for 2025 is projected to be 3,185 MBD of oil-equivalent, an increase from 2,925 MBD in 2024[37]. - The company has increased its production in Guyana, with 120 MBD in 2025 compared to no production in 2024[37]. - The company has a total of 472 MBD of production in Australia for 2025, slightly down from 479 MBD in 2024[37]. - The company has a total of 229 MBD of production in Africa for 2025, down from 267 MBD in 2024[37]. Workforce and Culture - Chevron's workforce consisted of 43,039 employees as of December 31, 2025, with 29% female representation[22]. - The company is focused on creating a diverse and inclusive work environment, rejecting quotas and making selection decisions based on merit[24]. - Chevron's total non-service station employees numbered 37,860, with 27% female representation and 73% male representation as of December 31, 2025[22]. - The company emphasizes the importance of operational excellence and employee safety, allowing employees to exercise stop-work authority to address unsafe conditions[25]. - Chevron aims to maintain a strong safety culture and environmental stewardship, with a focus on minimizing the impact of potential spills or leaks[169]. Strategic Direction and Goals - Chevron aims to safely deliver higher returns and lower carbon energy, leveraging its capabilities and partnerships to grow its oil and gas business[17]. - The company’s strategy focuses on delivering lower carbon energy while aiming for higher returns and superior shareholder value[17]. - Chevron's strategic direction includes lowering the carbon intensity of operations and expanding into new energy businesses[17]. - The company is investing in new energy solutions, including hydrogen and carbon capture technologies, to lower carbon intensity and create competitive returns[168]. Financial Overview - Chevron's financial condition and results of operations are discussed in detail in the Management's Discussion and Analysis section of the report[16]. - Chevron's average production cost per oil-equivalent barrel for 2025 is detailed in the financial statements, reflecting operational efficiency[31]. Exploration and Development - Chevron completed 1,059 productive wells in 2025, an increase from 804 in 2024[43]. - The company has a total of 386 wells drilling as of December 31, 2025, with 300 in the United States[43]. - Chevron's acquisition of Hess in 2025 expanded its pipeline infrastructure, enhancing its operational capabilities in the U.S.[158]. - Chevron was the apparent high bidder on 24 exploration blocks in the Gulf of America Big Beautiful Gulf 1 Lease Sale[70]. - Chevron secured nine additional offshore exploration blocks in Brazil, opening a new exploration frontier for the company[77]. - Chevron has a 30% nonoperated interest in the Stabroek Block, covering approximately 6.6 million acres, with an expected production capacity of 1.7 million gross barrels of oil per day by 2030[81]. - The One Guyana FPSO achieved first production in August 2025, with a capacity of approximately 250,000 gross barrels of oil per day, marking the fourth FPSO on the Stabroek Block[81]. - The Uaru development, sanctioned in April 2023, will utilize the Errea Wittu FPSO with a production capacity of approximately 250,000 gross barrels of oil per day, with first production expected in 2026[82]. - In 2025, Chevron was awarded a 90% working interest in exploration Blocks 5B and 6B offshore Guinea-Bissau[102]. Production Facilities and Capacity - Chevron's refining network had a capacity of 1.8 million barrels per day, with an average crude unit distillation capacity utilization of 92.9%[139]. - The expansion of the Pasadena Refinery became fully operational in 2025, increasing light crude oil throughput capacity to 125,000 barrels per day[141]. - Chevron's Gorgon LNG facility has a capacity of 15.6 million metric tons per year, with first gas from the Jansz-Io Compression project expected in 2028[128]. - In 2025, Chevron's Wheatstone LNG facility marked its 1,000th shipment since its commencement in 2017, with a capacity of 8.9 million metric tons per year[129]. - Chevron's Escravos Gas Plant in Nigeria has a total processing capacity of 680 million cubic feet per day of natural gas[109]. Environmental and Technological Initiatives - Chevron's Technology, Projects and Execution (TPE) organization focuses on innovation and operational excellence, supporting the delivery of cleaner energy solutions and holding over 4,000 patents[161][164]. - Chevron's marine fleet upgrades in 2025 included enhancements to four LNG vessels aimed at reducing emissions[160]. - Chevron's collaboration with startups and universities through Chevron Technology Ventures has supported over 140 startups in energy innovation[165]. - Chevron Phillips Chemical Company (CPChem) is constructing two major integrated polymer projects, with expected start-up in the first half of 2027, including the Golden Triangle Polymers Project in Texas and the Ras Laffan Petrochemical Project in Qatar[156]. - CPChem completed the Low Viscosity Poly Alpha Olefin Expansion Project in Belgium in 2025, enhancing its production capabilities[156].
J.B. Hunt Transport Services(JBHT) - 2025 Q4 - Annual Report
2026-02-24 19:47
J.B. HUNT TRANSPORT SERVICES, INC. (Exact name of registrant as specified in its charter) For the fiscal year ended December 31, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 OR FORM 10-K ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM _______ TO _______ ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 0-11757 (State or other jurisdiction of (I ...