Core Insights - Moderna reported a loss of 2.50pershareinQ42024,whichisanimprovementcomparedtotheZacksConsensusEstimateofalossof2.69 and a significant decline from earnings of 55 cents per share in the same period last year [1][2] - Total revenues for Q4 were 966million,exceedingtheZacksConsensusEstimateof956 million, but reflecting a year-over-year decline of approximately 64.3% due to lower product sales [2][3] - The company's stock has decreased by 65% over the past year, contrasting with a 3.6% decline in the industry [2] Financial Performance - Product sales fell by 66.4% year-over-year to 938million,primarilyduetoasignificantdropinSpikevaxsales[3][4]−Spikevaxsalesamountedto923 million in Q4 2024, down from 2.8billioninthepreviousyear,attributedtotheearlierlaunchofanupdatedCOVID−19vaccine[4]−SalesfromtherecentlylaunchedRSVvaccine,mResvia,wereminimalat15 million, with management expecting low sales in the quarter [5][9] - Total revenues for 2024 were 3.2billion,markinga52.99.28 per share, an improvement from a loss of 12.33pershareintheprioryear[11]FutureGuidance−For2025,Modernaexpectstotalrevenuesbetween1.5 billion and 2.5billion,primarilyfromCOVID−19andRSVvaccinesales,withaZacksConsensusEstimateof2.30 billion [12] - The company anticipates R&D expenses of around 4.1 billion and SG&A expenses of approximately 1.1 billion for 2025 [13] Pipeline Developments - Moderna submitted three regulatory filings to the FDA in Q4 2024, including for mRNA-1283 (next-generation COVID-19 vaccine) and mRNA-1083 (COVID-19 and influenza combination vaccine), with decisions expected in 2025 [14][15] - The company is also advancing over 40 mRNA-based investigational candidates, including those targeting cancer, with several in late-stage studies [17][18] - A registrational study for mRNA-3705, a therapeutic candidate for methylmalonic acidemia, is planned for later in 2025 [19]