BeiGene Discontinues Lung Cancer Drug Study After Interim Data Showed Limited Survival Benefit

Core Viewpoint - BeiGene Ltd has announced the discontinuation of its clinical development program for ociperlimab (BGB-A1217), an anti-TIGIT antibody, for lung cancer treatment based on a recommendation from the Independent Data Monitoring Committee following a futility analysis [1][2][3]. Group 1: Clinical Trial Details - The Phase 3 AdvanTIG-302 trial was evaluating the efficacy and safety of ociperlimab in combination with tislelizumab compared to Merck's Keytruda (pembrolizumab) in adults with high PD-L1, locally advanced/recurrent, or untreated metastatic non-small cell lung cancer (NSCLC) [2]. - The overall efficacy and safety data indicated that the trial was unlikely to meet its primary endpoint of overall survival [2][3]. - The study was originally expected to conclude in February 2027 [3]. Group 2: Company Strategy and Future Plans - BeiGene's decision to terminate the trial reflects a strategic evaluation of its clinical programs, focusing resources on the most promising candidates while deprioritizing others [3]. - No new safety signals were observed during the trial, which contributed to the decision to discontinue [3]. Group 3: Market Reaction - Following the announcement, BeiGene's stock (ONC) experienced a decline of 4.2%, trading at $263.04 [4].