Core Insights - The first quarter of 2025 was challenging for the S&P 500 and Nasdaq Composite, with losses of 4.6% and 10.4% respectively, impacting shares of Moderna which fell by 31.8% [1] - Moderna's revenue has significantly declined post-pandemic, with 2022 sales of 19.3billiondroppingtojust3.2 billion in 2024, reflecting a more than 50% year-over-year decline [2] - The company has lowered its sales guidance for 2025 to a range of 1billion,downfrompreviousexpectationsof2.5 billion to 3.5billion,indicatingweakeneddemandforitsvaccines[3]FinancialPerformance−Moderna′ssaleshaveplummetedsincethepandemic,withastarkcontrastbetween2022and2024figures[2]−Thecompanyisnowprojectingsalesfor2025tobebetween1.5 billion and 2.5billion,asignificantreductionfromearlierforecasts[3]Cost−CuttingMeasures−Inresponsetodecliningrevenues,Modernaisacceleratingcost−cuttingplansaimedatreducingexpensesby1 billion in 2025 [4] Regulatory Environment - The resignation of Peter Marks, a key FDA official, has raised concerns among investors, as it may lead to delays in vaccine development programs [5][6] - The political climate surrounding the FDA has been described as a "significant negative" for biotech and biopharma companies, particularly for vaccine manufacturers like Moderna [6]