美国生物医药数据库对华“断链”，中国科研人员呼吁开放原始数据

Core Viewpoint - UK BioBank emphasizes the importance of its database for global health and disease research, particularly in light of recent restrictions imposed by the NIH on data access for researchers in China and other countries [1][4][5]. Group 1: Impact of NIH Restrictions - The NIH has prohibited access to its controlled databases, including the SEER database, for researchers from specific countries, including China, effective April 4, 2025 [4][8]. - The SEER database is crucial for cancer research, covering data from 48% of the U.S. population, and has been relied upon by approximately 75% of cancer epidemiology papers published by Chinese scholars [9][10]. - The restrictions have raised concerns about a potential "cold war" in scientific research, with fears that other databases may follow suit in limiting access for Chinese researchers [5][10]. Group 2: Need for Domestic Data Sharing - Chinese research institutions must enhance their capabilities and promote scientific data sharing to avoid being significantly hindered by international restrictions [6][10]. - The current state of biomedical research in China shows a significant reliance on foreign databases, with 99% of pharmaceuticals and 100% of databases not being domestically sourced [13][14]. - Since 2004, China has made efforts to build national scientific data sharing platforms, but challenges remain in the implementation and effectiveness of these initiatives [15][17]. Group 3: Challenges in Data Sharing - There is a systemic lack of focus on scientific data development in China, with many efforts being limited to small teams rather than a cohesive national strategy [17][18]. - The reliance on foreign databases in educational institutions hampers the development of domestic data products, which, despite having competitive potential, struggle due to low user engagement [18][19]. - The phenomenon of "false sharing" is prevalent, where databases are claimed to be open but are not genuinely accessible, leading to a cycle of underutilization and slow development [21][22].