Core Viewpoint - The American Association for Cancer Research (AACR) annual meeting will showcase the latest preclinical research results of five innovative drugs developed by the company, highlighting its advancements in cancer treatment [1]. Group 1: Drug Innovations - CS2009 is a trispecific antibody targeting PD-1, VEGFA, and CTLA-4, designed to enhance efficacy while minimizing systemic toxicity, showing superior antitumor efficacy in preclinical studies compared to potential competitors [2]. - CS5006 is a first-in-class ADC targeting ITGB4, demonstrating strong antitumor activity in various animal models, indicating its potential for further clinical development [2]. - CS2011 is a bispecific antibody targeting EGFR and HER3, which effectively blocks downstream signaling and enhances antitumor efficacy while minimizing toxicity to normal tissues [3]. - CS5007 is an ADC that targets EGFR and HER3, showing promising antitumor activity through the release of chemotherapy agents in a target-dependent manner [6]. - CS5005 is an ADC targeting SSTR2, exhibiting robust antitumor activity and maintaining pharmacokinetic characteristics comparable to monoclonal antibodies [8]. Group 2: Research Presentation Details - CS2009 will be presented at the AACR meeting with a focus on its mechanism of action and safety profile, including a maximum non-severe toxicity dose of 100 mg/kg [4]. - CS5006 will be showcased for its potential as a novel integrin β4-targeted ADC with significant antitumor activity [5]. - CS2011 will be highlighted for its promising anti-tumor activity in preclinical evaluations, demonstrating effective inhibition of EGFR/HER3 signaling [5]. - CS5007 will be presented for its potent antitumor activity and favorable pharmacokinetic profile [6]. - CS5005 will be discussed for its potential in targeting SSTR2-positive tumors and its promising development as a dual-targeting ADC [8].
基石药业(02616)将携5项最新研究成果精彩亮相AACR 2025