Core Viewpoint - Bristol-Myers Squibb Company (BMY) reported strong first-quarter 2025 results, with adjusted earnings per share (EPS) of 1.80,exceedingexpectations,despiteadeclineinoverallrevenuesduetolegacyportfoliosales[1][20].FinancialPerformance−AdjustedEPSof1.80 beat the Zacks Consensus Estimate of 1.51andimprovedfromanadjustedlossof4.40 in the same quarter last year [1]. - Total revenues reached 11.2billion,surpassingtheZacksConsensusEstimateof10.7 billion, although down 6% from the previous year [1]. - U.S. revenues decreased 7% to 7.9billion,whileinternationalrevenuesfell23.3 billion [3]. Growth Portfolio - Revenues from the Growth Portfolio amounted to 5.6billion,reflectinga162.26 billion, up 9%), Reblozyl (478million,up35263 million, up 146%) [5][6][7]. - The Growth Portfolio's performance was bolstered by higher demand for Opdivo, Reblozyl, Breyanzi, Camzyos, Yervoy, and Opdualag [4]. Legacy Portfolio - Revenues from the Legacy Portfolio declined 20% to 5.64billion,primarilyduetogenericcompetitionaffectingdrugslikeRevlimidandPomalyst[10].−Eliquissaleswere3.56 billion, down 4%, but exceeded expectations [10]. - Revlimid revenues plummeted 44% to 936million,whilePomalystandSprycelalsosawsignificantdeclines[12].CostManagement−Grossmargindecreasedto73.12.2 billion, and adjusted marketing, selling, and administrative expenses fell 20% to 1.6billionduetocost−cuttinginitiatives[13].GuidanceUpdate−Thecompanyraiseditsannualrevenueguidanceto45.8-46.8billion,upfrom45.5 billion, reflecting strong Growth Portfolio performance and favorable foreign exchange impacts [17]. - Adjusted EPS guidance was also increased to a range of 6.70−7, compared to the previous guidance of 6.55−6.85 [18]. Pipeline Developments - The FDA approved Opdivo plus Yervoy as a first-line treatment for unresectable or metastatic hepatocellular carcinoma [16]. - Updates on Camzyos and Cobenfy indicated some challenges in clinical trials, with the latter not meeting statistical significance for its primary endpoint [15].