中年发福的真正原因找到了，这种细胞正在你的体内悄悄疯长

Core Insights - The article discusses the phenomenon of increased fat accumulation in middle-aged individuals, particularly focusing on the role of adipose progenitor cells (APCs) and their enhanced ability to generate new fat cells as people age [1][3][6] Group 1: Mechanisms of Fat Accumulation - The increase in individual fat tissue occurs through two main processes: hypertrophy (enlargement of fat cells) and adipogenesis (generation of new fat cells) [3] - Contrary to previous beliefs that APCs decrease in proliferation with age, recent studies show that APCs in middle-aged individuals actually become more active, leading to increased fat cell generation [3][5] Group 2: Research Findings - In studies involving male mice aged 12 months (equivalent to approximately 45 years in humans), significant increases in body weight and fat tissue were observed, with visceral fat increasing by 4.6 times and subcutaneous fat by 2.8 times [3] - Over 80% of the fat cells in the visceral fat tissue of these older mice were newly generated, indicating a robust adipogenesis process [3] Group 3: Identification of New Cell Types - Researchers identified a new subgroup of adipose progenitor cells, termed CP-A cells, which emerge around 9 months of age in mice and peak at 12 months [5] - These CP-A cells exhibit strong proliferation and differentiation capabilities, contributing to the active generation of fat cells in middle-aged individuals [5][6] Group 4: Implications for Human Health - Similar CP-A cell populations were found in human adipose tissue, suggesting that humans may experience analogous changes in fat cell dynamics as they age [6] - The study identified the leukemia inhibitory factor receptor (LIFR) as a crucial molecule for fat generation in CP-A cells, indicating potential therapeutic targets for preventing middle-aged obesity [6]