BEAM Stock Down 19% as Q1 Earnings & Revenues Miss Estimates

Core Insights - Beam Therapeutics reported a wider loss of $1.24 per share for Q1 2025, compared to the Zacks Consensus Estimate of a loss of $1.11 and a loss of $1.21 per share in the same quarter last year [1] - Total revenues for the first quarter were $7.5 million, slightly up from $7.4 million year-over-year, but below the Zacks Consensus Estimate of $15 million [2] - The company's stock fell 19.3% on May 6 due to disappointing Q1 results, and it has declined 35.6% year-to-date, while the industry has only declined by 2.8% [2][3] Financial Performance - Research and development expenses increased to $98.8 million in Q1, up nearly 16.5% from the previous year [4] - General and administrative expenses rose to $27.9 million, an increase of around 4.5% year-over-year [4] - As of March 31, 2025, Beam Therapeutics had cash and marketable securities totaling $1.20 billion, up from $850.7 million as of December 31, 2024, and expects this to fund operations into 2028 [5] Pipeline Developments - The company is advancing its ex-vivo genome-editing candidate, BEAM-101, in a phase I/II BEACON study for treating adult patients with sickle cell disease, aiming to dose 30 patients by mid-2025 [6] - Beam is also expanding its pipeline with BEAM-301 and BEAM-302 for glycogen storage disease type 1a and alpha-1 antitrypsin deficiency, respectively [8] - Initial safety and efficacy data for BEAM-302 showed promising results, with treatment leading to significant increases in total and functional alpha-1 antitrypsin levels and reductions in toxic mutant Z-AAT [10][11] - The FDA has cleared the IND application for BEAM-302, and the company is activating study sites in the U.S. [13]