左氧氟沙星可能导致跟腱断裂？专家这样回答→

Core Viewpoint - The discussion around the potential risk of tendon rupture associated with levofloxacin has gained attention, with many individuals unaware of this side effect [1][2] Summary by Sections Drug Overview - Levofloxacin is a commonly used fluoroquinolone antibiotic, widely prescribed for various infections due to its broad antibacterial spectrum and strong efficacy [2] - In 2022, the total prescription volume of levofloxacin in China reached 48 million [2] Risk of Tendon Rupture - The incidence of tendon rupture due to levofloxacin is reported to be 3-5 cases per 10,000 users [2] - Although the relative risk of tendon rupture is higher compared to other medications, the absolute probability remains low [2] High-Risk Populations - Five specific groups are identified as high-risk for tendon rupture when using levofloxacin: - Individuals aged over 60, due to decreased tendon flexibility and blood supply [4] - Patients using corticosteroids, which can adversely affect tendons and increase rupture risk when combined with fluoroquinolones [5] - Patients with renal insufficiency, as impaired kidney function can elevate drug concentration and adverse effects [6] - Organ transplant recipients, who often take immunosuppressants and may have a higher risk of side effects [6] - Athletes or individuals engaged in high-intensity physical activities, as their tendons are already under significant stress [7] Timing of Symptoms - Symptoms of tendon damage may appear within hours of taking the medication or up to six months after discontinuation, with most cases occurring within two weeks of use [4] Localized Use of Levofloxacin - The risk of significant side effects is low when using localized forms of levofloxacin, such as eye drops or ear drops, due to minimal absorption [9] - Caution is advised if both local and systemic forms of the drug are used simultaneously [9]