博瑞医药六连阳炒作成分偏多？减肥药“内卷”同质化显著 口服减肥药研发进度落后

Core Viewpoint - The acceptance of the IND application for BGM0504 by Borui Pharmaceutical has led to a significant increase in its stock price, but the competitive landscape in the weight loss market is intensifying, posing challenges for future commercialization [1][2][4]. Company Summary - Borui Pharmaceutical's BGM0504, a dual-target GLP-1/GIP receptor agonist, has seen its stock price rise significantly, recording a six-day consecutive increase with gains of 8.08%, 5.26%, 8.38%, 2.67%, 5.91%, and 14.73% over the specified trading days [1]. - The company has recently received clinical approval for its oral weight loss drug, but its development progress is notably behind competitors [1][8]. - BGM0504's injection formulation shows a weight loss of 18.5% in overweight or obese subjects, slightly outperforming similar products, but the overall efficacy differences among competing products are minimal, indicating significant product homogeneity [5][7]. Industry Summary - The domestic GLP-1 drug market is highly competitive, with around 40 companies developing GLP-1 drugs for weight loss, including various formulations such as peptides and small molecules targeting single, dual, and triple receptors [2][4]. - The market is expected to see a surge in generic drug entries as patents for key products like semaglutide are set to expire, leading to increased competition [4]. - The trend in GLP-1 drug development is shifting towards long-acting, multi-target, and oral formulations, with several companies, including Eli Lilly and Novo Nordisk, already having products in the market [5][6]. - Borui's BGM0504 is among the few multi-target products in clinical development, but it faces stiff competition from other companies with advanced pipelines [5][6].