史上引用量第一的论文，是哪篇？

Core Insights - The most cited research paper of all time is a 1951 paper published in the Journal of Biological Chemistry, detailing a method for determining protein content in solutions, with over 350,000 citations as of the latest statistics [1][4][10] - The owner of the Web of Science (WoS) database, Clarivate, reported that a significant portion of highly cited papers are related to biological experimental techniques, with the threshold for entering the top 100 citations rising from approximately 12,000 in 2014 to over 30,000 now [2][7] - An analysis of other databases, Dimensions and OpenAlex, shows slight variations in rankings, but the 1951 paper remains at the top across all platforms [3][4] Citation Trends - There are only three papers with over 200,000 citations, all related to biological experimental techniques, and the top three papers in the new ranking remain unchanged from 2014 [7] - Sixteen papers published in the 21st century have entered the historical top 50, indicating a significant rise in citations for software descriptions and computer-aided research results [8] - The increase in annual publication rates and the rise of online research and social media exposure are contributing factors to the rapid citation growth of newer papers [9] Future Projections - If the current citation growth rates continue, certain recent papers, such as those on AI and density functional theory (DFT), may surpass the 1951 paper by 2030 [10]