Hengrui Pharma(SH:600276) Zhong Guo Fa Zhan Wang·2025-07-25 08:43Core Viewpoint - The recent patent granted to Heng Rui Medical for its "Uniform Particle Size Drug-loaded Microspheres" technology marks a significant milestone for Chinese medical device innovation, enabling the company to break into the global market and enhance treatment options for liver cancer patients in China [1][2][5] Group 1: Patent Significance - The patent represents a breakthrough in drug-loaded microsphere technology, allowing for the first time a Chinese company to establish a foothold in the core technology and materials sector of this field [1][2] - This achievement is a key step towards the goal of "high-end medical equipment domestic substitution" as outlined in China's 14th Five-Year Plan [2][5] Group 2: Impact on Liver Cancer Treatment - The technology is expected to significantly reduce the cost and improve the accessibility of D-TACE (Drug-loaded Transarterial Chemoembolization) treatment for liver cancer patients in China, who have been facing high costs associated with imported materials [2][4] - The patent addresses the critical issue of low early diagnosis rates and high recurrence rates in liver cancer treatment, which currently sees a 5-year survival rate of only 12% for late-stage patients [1] Group 3: Technological Advancements - Heng Rui Medical's patented technology achieves a remarkable control of particle size variation (CV value) at below 5%, setting a new global standard for microsphere manufacturing precision [3][4] - The innovation allows for a shift from empirical to personalized precision embolization in D-TACE, laying the groundwork for future integration with other innovative treatment modalities [3] Group 4: Market Dynamics - The patent is expected to disrupt the existing market dominated by foreign companies, which have historically controlled 90% of the drug-loaded microsphere market through patent barriers [4] - With the release of domestic high-quality microsphere production, the company aims to accelerate the process of import substitution and enhance the security of the domestic supply chain [4]