Keros to Exclusively Prioritize the Clinical Advancement of KER-065

Core Viewpoint - Keros Therapeutics is discontinuing the development of cibotercept to focus on its key clinical program, KER-065, which is aimed at treating Duchenne muscular dystrophy (DMD) [1][2][4] Strategic Realignment - The company will cease all internal development activities related to cibotercept following the termination of its development in pulmonary arterial hypertension (PAH) due to safety and efficacy data from the TROPOS Phase 2 clinical trial [2] - Keros is reallocating resources to enhance the development of KER-065, which has shown promising results in initial clinical trials [1][4] Leadership Changes - Keros announced several transitions in its Board of Directors and leadership to support its streamlined operational structure [3][5] - Jasbir S. Seehra, Ph.D., will take on the additional role of President while stepping down as Chair of the Board, with Jean-Jacques Bienaimé appointed as the new Chair [5] - Christopher Rovaldi will leave the company, and Lorena Lerner, Ph.D., will be promoted to Chief Scientific Officer [5] Clinical Development Plans - Keros plans to initiate a Phase 2 clinical trial for KER-065 in patients with DMD in the first quarter of 2026, pending positive regulatory interactions [4] - The company has reported initial topline results from the Phase 1 clinical trial of KER-065, achieving key objectives related to safety, tolerability, pharmacokinetics, and pharmacodynamics [4] Financial Results - Keros has released its financial results for the second quarter ended June 30, 2025, which can be accessed on its website [6]