Significant Withhold Votes from Directors Mary Ann Gray and Alpna Seth Underscores Need for Change and a More Disciplined Capital Allocation StrategyAUSTIN, Texas, June 9, 2025 /PRNewswire/ -- ADAR1 Capital Management, LLC (together with its affiliates, "ADAR1" or "We"), the largest stockholder of Keros Therapeutics (Nasdaq: KROS) ("Keros" or the "Company"), today issued the following statement regarding the results of the Company's 2025 Annual Meeting of Stockholders (the "Annual Meeting"):"We believe the ...

Keros Therapeutics (KROS) FY 2025 Conference June 09, 2025 09:20 AM ET Speaker0 Thanks for joining us here at the Goldman Sachs Global Healthcare Conference. We are joined today on stage by Jas from KAROS, and maybe we will kick it off just kind of an overview. So I'd love if you could provide kind of an overview of KAROS as it stands today, recognizing there were some new news as well this morning. And can you focus also on what you see as sort of the value drivers of the company over the next, let's say, ...

Concludes Strategic Alternatives Review and Provides Update on Development of KER-065LEXINGTON, Mass., June 09, 2025 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros” or the “Company”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (“TGF-ß”) family of proteins, today announced that the Company has concl ...

LEXINGTON, Mass., June 06, 2025 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (“TGF-ß”) family of proteins, today announced that Keros’ Chair and Chief Executive Officer Jasbir S. Seehra, Ph.D., will participate in a fireside chat presentation at the G ...

Discontinues Development of Cibotercept in PAH Announces Corporate Restructuring to Align Operations with Ongoing Strategic Priorities LEXINGTON, Mass., May 29, 2025 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros”, the “Company” or “we”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (“TGF-ß”) family ...

Keros Board Best Equipped to Oversee Strategic Review Process and Execute on Ultimate Outcome of that Process ADAR1’s Disruptive and Self-Serving Campaign Stands to Jeopardize the Future Value Maximizing Potential of the Company Keros Urges Stockholders to Protect the Value of Their Investment by Voting “FOR” All Three of the Company’s Highly Qualified Director Nominees LEXINGTON, Mass., May 27, 2025 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros”, the “Company” or “we”) (Nasdaq: KROS), a clinical-st ...

ADAR1 Urges Board to Release Strategic Review Results Before, Not After, Annual Meeting ADAR1 Capital Management is an SEC-registered investment manager based in Austin, Texas, focused on public and private equity investments in the life sciences and biotechnology sectors. The firm was founded in October 2018 by Dr. Daniel Schneeberger, who brings over 20 years of experience spanning scientific research, healthcare consulting, institutional investing, and executive leadership in the healthcare industry. He ...

Summary of Keros Therapeutics and Tiara Biosciences Conference Calls Keros Therapeutics (KROS) Industry Overview - Keros Therapeutics focuses on the TGF beta pathway, which is crucial for embryogenesis and tissue maintenance. Dysregulation of this pathway is linked to various diseases [3][4]. Core Pipeline - Keros has three main assets: 1. **Aridrocept 50**: A ligand trap for MDS and myelofibrosis, partnered with Takeda, showing promising economics [5]. 2. **Cibodocept**: A trial for pulmonary arterial hypertension (PAH) was terminated early due to safety signals, with top-line data expected soon to determine the next steps [6][10]. 3. **A third ligand trap**: Targets negative regulators of skeletal muscle, enhancing muscle regeneration and improving bone mineral density, suitable for neuromuscular indications [6][7]. Financial and Strategic Challenges - An activist investor has challenged Keros' leadership, prompting the company to explore strategic alternatives to maximize pipeline value [8][10]. - The stock has declined below cash levels, leading to a reassessment of the company's strategy [10]. Clinical Development Insights - Aridrocept is in a Phase 3 trial for MDS, with potential annual sales projected to reach $2 billion if approved for frontline treatment [15][16]. - The company aims to demonstrate that Cibodocept can be effective in PAH, despite recent safety concerns [22][23]. - The CEO emphasizes the importance of patient quality of life and transfusion independence in treatment outcomes [19][21]. Tiara Biosciences Industry Overview - Tiara focuses on small molecule precision medicines, particularly in the FGFR family, with a lead molecule that is FGFR3 selective [34][35]. Unique Platform - The Snap Chemistry Design Platform allows for the development of selective FGFR3 inhibitors, differentiating Tiara from other developers that use pan FGFR inhibitors [35][36]. Clinical Development and Market Potential - Tiara is addressing unmet needs in non-muscle invasive bladder cancer (NMIBC) and achondroplasia, with a focus on oral therapies that can reduce recurrence rates compared to current treatments [39][40]. - The company anticipates generating top-line results from ongoing trials, with a focus on complete response rates as early efficacy signals [44][45]. Competitive Landscape - Tiara's FGFR3 inhibitor is positioned to have a better safety profile compared to existing therapies, with lower rates of adverse effects such as nail toxicity and stomatitis [56][57]. - The company aims to exceed existing benchmarks for height velocity in achondroplasia treatments, targeting an annualized height velocity of 8-8.5 cm [62][53]. Financial Position - Tiara is well-capitalized, with sufficient funds to support operations through 2027, allowing for strategic prioritization of its clinical programs [64][65]. Conclusion - Both Keros Therapeutics and Tiara Biosciences are navigating complex clinical landscapes with innovative therapies aimed at significant unmet medical needs. Keros is focusing on maximizing the value of its pipeline amidst strategic challenges, while Tiara is leveraging its unique platform to differentiate itself in the FGFR inhibitor market.

Core Viewpoint - ADAR1 Capital Management, the largest stockholder of Keros Therapeutics, is advocating for withholding votes on the re-election of two board members at the upcoming Annual Meeting of Stockholders scheduled for June 4, 2025 [1]. Company Overview - ADAR1 Capital Management holds approximately 13.3% of Keros Therapeutics' outstanding shares, indicating a significant stake in the company [1]. - The firm is based in Austin, Texas, and focuses on public and private equity investments in the life sciences and biotechnology sectors [3]. Leadership Background - Dr. Daniel Schneeberger, the founder of ADAR1, has over 20 years of experience in scientific research, healthcare consulting, institutional investing, and executive leadership in the healthcare industry [3]. - The team at ADAR1 consists of experienced professionals with deep medical and scientific expertise, emphasizing their strong track record in biopharmaceutical investing [3].

LEXINGTON, Mass., May 12, 2025 (GLOBE NEWSWIRE) -- Keros Therapeutics, Inc. (“Keros”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapeutics to treat a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (“TGF-ß”) family of proteins, today announced that Keros’ Chair and Chief Executive Officer Jasbir S. Seehra, Ph.D., will participate in a fireside chat presentation at the Ba ...