Ge Long Hui·2025-08-21 00:43Group 1 - The core viewpoint of the report is that Everbright Securities has raised its net profit forecast for Gilead Pharmaceuticals for the first half of 2025 due to increased clinical research investment in metabolic disease treatment and lower-than-expected R&D expenses in the first half of the year, while maintaining a "buy" rating [1] Group 2 - Gilead Pharmaceuticals' ASC30 is positioned as a potential leading GLP-1 small molecule weight loss drug, with Phase Ib clinical data showing a 6.5% average weight reduction over 28 days in obese patients compared to baseline, excluding placebo effects [2] - The subcutaneous injection of ASC30 has a half-life of 36 days in obese patients, supporting low-frequency dosing, and the company is advancing both oral and subcutaneous Phase IIa clinical trials, expecting top-line data in Q4 2025 and Q1 2026 [2] - In contrast, Eli Lilly's oral GLP-1 small molecule weight loss drug Orforglipron showed lower-than-expected weight loss data over 72 weeks, enhancing the overseas business collaboration value and expectations for ASC30 [2] - Another drug, ASC47, combined with GLP-1 peptide drugs, shows potential for weight loss without muscle loss, with Phase Ib trials indicating a 1.7% weight reduction after a single 90mg subcutaneous injection on day 50, with no muscle loss observed [2] - Preclinical animal studies suggest that ASC47 combined with semaglutide has superior weight loss effects compared to monotherapy, maintaining muscle mass similar to healthy mice, and the company is conducting U.S. clinical trials for ASC47 combined with semaglutide, expecting top-line data in 2025 [2]