从海外授权到NewCo，美元基金变相杀回中国创新药

Group 1 - The focus of US funds on Chinese innovative drugs has not diminished, but the approach has shifted to overseas asset placement to reduce compliance risks and enhance capital efficiency [1][5] - The recent surge in Hong Kong's 18A projects is driven by high-frequency BD collaborations, NewCo models, and mergers and acquisitions, fundamentally changing the underlying logic of the innovative drug sector [1][3] - In 2024, the number of innovative drugs under development in China is projected to reach 3,575, surpassing the United States and establishing China as a global leader in this area [3] Group 2 - The NewCo model has gained traction, particularly in oncology and autoimmune disease treatment, allowing Chinese companies to collaborate with US funds to establish new entities for global development [2][4] - The BD and NewCo strategies are key drivers of the innovative drug market, with significant overseas licensing deals becoming commonplace, exceeding $1 billion [3][4] - The NewCo model allows Chinese pharmaceutical companies to retain equity while receiving upfront payments, milestones, and revenue sharing, thus mitigating direct investment risks for US funds [4][5] Group 3 - The investment landscape for US funds in China is evolving, with a focus on incubating NewCo and injecting assets into these entities to avoid direct investment risks associated with Chinese companies [5][6] - Despite a decrease in direct investments by US funds in Chinese biotech, the understanding of the market has deepened, leading to a strategic shift towards acquiring Chinese assets and forming US-based companies [6][7] - The trend of Chinese innovative drugs going global is accelerating, with an emphasis on having clear "going out" strategies to attract international partnerships and acquisitions [8][9] Group 4 - The current focus of capital is on large products and indications, particularly in oncology and autoimmune diseases, with a notable trend towards metabolic drugs driven by successful GLP-1 products from multinational companies [9][10] - The innovative drug market in China is increasingly recognized for its potential to be acquired by global pharmaceutical companies, moving away from a reliance on domestic sales and channels [8][9]