重大突破！中国团队成功完成世界首例基因编辑猪肺移植人体手术【附基因编辑行业市场分析】

Group 1 - The core viewpoint of the article highlights the advancement of xenotransplantation technology, particularly the successful transplantation of gene-edited pig lungs into a brain-dead human, which may address the global shortage of lung transplant donors [2] - The research team from Guangzhou Medical University has achieved a significant milestone by performing the world's first gene-edited pig lung transplant, with the transplanted lung maintaining ventilation and gas exchange functions for 9 days without acute rejection or infection [2] - The next steps involve optimizing gene editing strategies and anti-rejection treatment plans to extend the function of transplanted organs to months or longer, aiming to push xenogeneic lung transplantation into clinical application [2] Group 2 - The gene editing industry has rapidly developed, primarily applied in agriculture and disease treatment, with significant potential for crop breeding and livestock improvement [3] - CRISPR/Cas9 technology is identified as the most advantageous among gene editing techniques due to its high cutting efficiency and commercial potential [5] - The gene editing of the donor pig involved knocking out genes that cause human immune rejection and inserting human immune regulatory genes, creating a "humanized" pig organ model that reduces the risk of immune system attacks [8]