乐普医疗(300003.SZ)：MWN105注射液Ⅱ期临床试验完成首例受试者给药

Core Viewpoint - Lepu Medical announced that its subsidiary, Shanghai Minwei Biotechnology Co., Ltd., has initiated a Phase II clinical trial for its innovative drug MWN105 injection, aimed at treating overweight or obesity, successfully completing the first dosing of a subject [1] Group 1 - MWN105 injection is a triple agonist targeting GLP-1/GIP/FGF21 receptors, with global intellectual property rights [2] - Preclinical results indicate that MWN105 injection significantly reduces random blood glucose, fasting blood glucose, and glycated hemoglobin in db/db mouse models, while increasing the proportion of pancreatic β-cells and improving glucose tolerance [2] - In DIO obese mouse models, MWN105 injection shows significant reductions in body weight, fat content, and liver weight, as well as decreased food intake, low-density lipoprotein cholesterol (DL-C), total cholesterol (TC), and improved liver function [2] Group 2 - In the B6-A1ms1-de1 mouse MASH model, MWN105 injection significantly reduces body weight, liver weight, and liver-to-body ratio, while lowering plasma ALT, AST, CHOL, LDL-C levels, and liver CHOL and TG content, and significantly improving liver NAS scores [2] - In spontaneously MASH monkeys with metabolic disorders, MWN105 injection can reduce animal body weight and HbA1c levels, significantly lower liver fat content, liver NAS scores, and the proportion of liver fibrosis positivity, inhibiting the progression of liver fibrosis [2] - Safety evaluation tests indicate that MWN105 injection has good safety profiles [2]