Lilly(US:LLY) Zheng Quan Ri Bao·2025-09-18 08:38Core Insights - Diabetes is a global public health challenge, with over 500 million patients worldwide, predominantly suffering from type 2 diabetes. China faces a significant burden in diabetes management [1] - Eli Lilly's ACHIEVE-3 study provides new insights into managing type 2 diabetes, comparing orforglipron and oral semaglutide, showing orforglipron's superior efficacy in reducing A1C levels and weight loss [1][2] - The study indicates that orforglipron leads to a 2.2% reduction in A1C levels compared to 1.4% for oral semaglutide, and participants on orforglipron lost an average of 8.9 kg (9.2%) versus 5.0 kg (5.3%) for semaglutide [1][2] Group 1 - Orforglipron shows significant improvements in cardiovascular risk factors, including non-HDL cholesterol, systolic blood pressure, and triglycerides, while maintaining safety and tolerability [2] - The research expands chronic disease management pathways, providing more tools for personalized treatment plans, which is crucial for long-term diabetes management [2] - The ATTAIN-1 study also demonstrated that orforglipron can aid in weight loss and improve cardiovascular risk factors in overweight or obese individuals without diabetes [2] Group 2 - Eli Lilly emphasizes the importance of convenient medication options for early management of metabolic disorders, shifting the focus from treatment to prevention [3] - The company is advancing orforglipron's application for obesity treatment globally, with regulatory approval expected soon, while the application for type 2 diabetes treatment is anticipated in 2026 [3] - The innovation in drug development is expected to translate into accessible health benefits for the public, contributing to overall health goals [3]