整理 | GLP1减重宝典内容团队 研究人员在监测一名严重暴食患者的大脑活动时发现，礼来的GLP-1减重药物似乎能暂时抑制大脑"奖励中心"中的食物渴望信号。这是 首次对接受替尔泊肽治疗的个体进行直接脑活动测量，为该药物对所谓"食物噪音"的影响提供了新的线索。 研究团队指出，这项发表的报告仅基于一个病例，结果无法推广，但可能意味着未来版本的替尔泊肽或其他GLP-1药物在治疗部分饮食 障碍方面具有潜力。研究负责人、宾夕法尼亚大学佩雷尔曼医学院的Casey Halpern博士表示，希望这项研究能激发更深入的探索。 该研究纳入了四名参与首个用于治疗暴食、暴饮暴食等失控型饮食障碍的深部脑刺激临床试验的受试者。研究目标是在大脑奖励中枢 ——伏隔核内监测神经活动，并利用植入式装置阻断在暴食发作前逐渐增强的信号。 其中一名受试者因为2型糖尿病和肥胖，在植入电极前已被处方替尔泊肽。在最初几个月的监测中，她没有出现食物相关的侵入性思 维，其伏隔核中也未出现食物渴望信号。相比之下，未使用替尔泊肽的参与者则表现出典型的伏隔核高活跃度，并伴随频繁的食物执 念。研究人员认为，这种显著安静的神经信号与行为表现表明替尔泊肽可能在短期内降低了 ...

In this week’s edition of InnovationRx, we look at the price cuts for blockbuster weight-loss drugs, the Forbes 30 Under 30 Healthcare list, the coming barriers to getting vaccines, and more. To get it in your inbox, subscribe here.gettyMore people may be able to afford GLP-1 weight-loss drugs following a flurry of recent announcements to cut prices and increase insurance coverage.On Monday, Eli Lilly dropped prices for single-dose vials of its blockbuster weight-loss drug Zepbound for cash-paying customers ...

A key catalyst may be right around the corner.Eli Lilly (LLY 0.91%) stock recently reached a big milestone, surpassing the level of $1,000. This wasn't too much of a surprise as the shares have marched higher in recent years thanks to the company's strengths in a high-growth area: the weight loss drug market. Demand for these drugs has been so strong that they even spent last year on the U.S. Food and Drug Administration's shortage list.Though Lilly stock has climbed more than 100% over the past three years ...

Key TakeawaysEli Lilly's Pirtobrutinib (Jaypirca) received full FDA approval, significantly expanding its market for adults with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL).Glencore (GLEN) announced the restart of its Alumbrera copper mine in Argentina, signaling a long-term strategy to boost copper production to 1.6 million tons by 2035, despite a cut in its 2026 output guidance.Belgium has voiced strong opposition to the European Union's plan to utilize froz ...

19 (2.7-5%), and pneumonia (3.4%).**Dose Modifications and Discontinuations Due to ARs:**Dose reductions in 3.6-10%, treatment interruption in 42-51%, and permanent discontinuation of Jaypirca in 9-17% of patients. Permanent discontinuation in >>1% of patients included second primary malignancy, pneumonia, COVID- 19, neutropenia, sepsis,anemia, and cardiac arrythmias.**Most common ARs and Select Laboratory Abnormalities (20%) (all Grades %, Grade 3-4 %)--in a randomized controlled trial:**neutrophil count d ...

Key Points These two market leaders boast significant growth prospects in their niches. They increased their payouts at a good clip over the past decade. 10 stocks we like better than Microsoft › Most companies worth $1 trillion or more are leaders in their respective industries and boast excellent long-term growth prospects. Hardly any of them are known for their dividends, but several do offer competitive income programs that arguably make them even more attractive. That's the case with Microsoft ...

美银将礼来的目标价从950美元大幅上调至1286美元，并重申"买入"评级。分析师看好礼来的核心理由 在于其GLP-1药物Zepbound和Mounjaro在大型肥胖症和糖尿病市场中保持"第一名"地位。尽管该领域竞 争复杂，但礼来仍稳居领先地位。此外，礼来的新药开发进度快于预期，分析师预计口服药物 orforglipron将于2026年初，而非此前预期的2026年末推出，这推升了其对该公司未来一年的营收和盈利 预测。 ...

Market Overview - The cryptocurrency market has stabilized, leading to a rise in Bitcoin and tech stocks, which boosted trading sentiment and resulted in slight gains for the three major stock indices [1] - As of the market close, the S&P 500 index rose by 0.25% to 6829.37 points, the Nasdaq Composite increased by 0.59% to 23413.67 points, and the Dow Jones Industrial Average gained 0.39% to 47474.46 points [1] Market Sentiment and Predictions - The market is awaiting catalysts for a potential "Santa Rally," with more stocks declining than rising in the S&P 500 [3] - Analysts suggest that the market may need to consolidate before reaching new highs, with a mixed outlook for December [3] Stock Performance - Notable stock movements include Nvidia up by 0.86%, Apple up by 1.09%, and Boeing up by 10.15% due to expectations of returning to positive cash flow by 2026 [3][4] - Conversely, some stocks like Broadcom and Tesla saw declines of 1.17% and 0.21% respectively [3] Cryptocurrency and Related Stocks - Bitcoin's rebound of 6% positively impacted related stocks like MSTR and BMNR, while ABTC, linked to the Trump family, plummeted by 38% due to a lock-up expiration [6] - The Nasdaq China Golden Dragon Index fell by 0.65%, with Alibaba down by 1.91% and NIO down by 2.9% [6] Company Developments - Nvidia's CFO stated that the $100 billion investment in OpenAI has not yet been included in revenue guidance, as it is still in the letter of intent stage [7] - Amazon AWS launched its first 3nm AI chip, Trainium3, which boasts a performance increase of 4.4 times compared to its predecessor [8] - AWS also introduced a new large model training service, Nova Forge, allowing businesses to customize training with proprietary data [9] Philanthropic Initiatives - Dell's founders announced a donation of $6.25 billion to help establish investment accounts for 25 million American children, with each account receiving $250 [10]

Question-and-Answer SessionIlya YuffaExecutive VP and President of Lilly USA & Global Customer Capabilities Sure. Well, good morning. Great to be here with everyone here. Obviously, last number of years, we've had a lot of progress across our portfolio. Last almost four years, I was Head of International, leading all the markets outside of the U.S. And our focus has been around -- I know lot of patience around the -- around supply and making sure that we can actually launch in so many markets. And we're see ...

Key Takeaways Eli Lilly cut prices for single-dose Zepbound vials purchased through its LillyDirect platform.New monthly prices range from $299 to $449, with all dose prices reduced from previous levels.The move follows a recent deal involving similar cuts for the multi-dose pen form of Zepbound.Eli Lilly (LLY) announced that it has lowered the price of single-dose vials of its blockbuster obesity drug, Zepbound (tirzepatide), purchased through the direct-to-consumer (DTC) platform LillyDirect.Starting this ...