防治前移再成议题，中山一院如何探索社区早筛阿兹海默新模式？

Core Viewpoint - Alzheimer's disease is a significant public health challenge in China, with over 10 million patients, the highest globally, and the importance of early screening and intervention is increasingly recognized [1][3]. Group 1: Current Situation and Challenges - The prevalence of Alzheimer's disease (AD) in China is approximately 16 million, with a staggering 50% prevalence in individuals aged 80 and above [3]. - Major barriers to early screening include insufficient funding and low public awareness, with many believing that "asymptomatic individuals do not need screening" [2][3]. - The current early screening system is based on international cooperation and utilizes digital tools for localized implementation, consisting of three steps: home screening via an app, community-assisted screening, and referral to hospitals for PET scans [3][4]. Group 2: Technological Advancements - Molecular imaging technology, particularly PET-CT, is crucial for early diagnosis, capable of detecting abnormal Aβ protein accumulation up to 10 years before clinical symptoms appear [5][6]. - The cost of PET-CT scans has significantly decreased, making early diagnosis more accessible, although challenges remain in public perception regarding affordability [5][6]. - The integration of digital cognitive assessments and blood tests into the diagnostic process enhances the precision of Alzheimer's disease management [5][6]. Group 3: Future Directions - Community involvement is essential for the success of early screening initiatives, with hospitals providing resources and communities handling initial screenings and follow-ups [4]. - Interventions targeting risk factors such as diabetes and hypertension can reduce disease progression by 40%-50%, with digital tools facilitating self-monitoring and timely medical consultation [7].