全球首款“骨胶水”研发团队：可实现断骨三分钟黏合

Core Viewpoint - Zhejiang University School of Medicine's Shao Yifu Hospital has developed the world's first biodegradable bone glue, "Bone 02," inspired by the adhesion mechanism of oysters, which can bond bone fragments effectively in a blood environment [1][2]. Summary by Sections Product Development - "Bone 02" is designed to bond bone fragments in various fracture types, potentially reducing or replacing traditional metal fixation methods [1]. - The development team conducted rigorous clinical trials over eight months, involving over 150 patients, demonstrating good safety and efficacy [1][2]. Technical Aspects - The material consists of a liquid phase and a solid phase, both of which are biocompatible and consist of components already present in the human body [3]. - The adhesive mechanism allows for rapid solidification within three minutes, creating a strong bond with bone tissue [4]. Performance Metrics - Key performance indicators include adhesion strength, operational time, and biocompatibility, which were optimized through extensive testing and iterations [5]. - The final formulation allows for a 3 to 5-minute operational window before solidification begins, ensuring sufficient time for precise application during surgery [5]. Clinical Advantages - Compared to traditional metal fixation, "Bone 02" reduces surgical time, minimizes tissue trauma, and accelerates recovery [11]. - The product's biodegradable nature eliminates the need for secondary surgeries to remove metal implants, thus reducing overall healthcare costs [15]. Future Applications - The technology is expected to shift orthopedic surgery paradigms from mechanical fixation to biological healing, with potential applications in various fields, including dental implants and spinal surgery [19][20]. - "Bone 02" is anticipated to be approved for widespread clinical use within the next two to three years [20]. Emergency Use - The product's simplicity and rapid application make it suitable for emergency situations, such as battlefield or disaster scenarios, where quick stabilization of injuries is critical [18].