Core Viewpoint - Shanghai Aikobio Pharmaceutical Technology Co., Ltd. has submitted a listing application to the Hong Kong Stock Exchange, with JPMorgan and CITIC Securities as joint sponsors. The company focuses on developing therapies for respiratory and pediatric diseases, with its core product, Ziresovir, being the first NDA-stage drug targeting respiratory syncytial virus (RSV) infection globally. However, the company has accumulated losses of 571 million yuan due to the product not yet being commercialized [1][4]. Company Overview - Aikobio was founded in 2013 and has not yet commercialized any products, remaining in a loss-making state. The company reported revenue of 6.7 million yuan in 2023 but has not generated further income since then. The revenue was related to a collaboration on a hepatitis B virus candidate drug, which has since been paused [4][5]. - The company has undergone multiple rounds of financing, with notable investors including Qiming Venture Partners, TF Capital, and Hillhouse Capital. In June 2022, Aikobio completed a Series D financing round, achieving a post-money valuation of 4.69 billion yuan [2][5]. Financial Performance - Aikobio has reported cumulative losses of 571 million yuan over two and a half years. The losses for the years 2020 to 2024 were 214 million yuan, 197 million yuan, 104 million yuan, 270 million yuan, and 197 million yuan, respectively. R&D costs were approximately 86 million yuan, with a year-on-year increase of 20.58% [4][5]. - The net cash flow from operating activities for 2023, 2024, and the first half of 2025 is projected to be -232.8 million yuan, -188.7 million yuan, and -71.7 million yuan, respectively. As of June 30, 2025, the company expects to have cash and cash equivalents of 96.74 million yuan [4]. Product Pipeline - Aikobio has developed six candidate drug pipelines, including Ziresovir, AK0610 (a monoclonal antibody for RSV prevention), and AK3280 (for idiopathic pulmonary fibrosis). The company has licensed several products from Roche, including Ziresovir, which is currently in the NDA stage [6][7]. - Ziresovir is specifically designed to treat RSV infections, a common and contagious RNA virus that causes respiratory diseases, particularly in vulnerable populations. The company submitted the NDA for Ziresovir to the National Medical Products Administration in August 2025 [7]. Market Competition - Although Ziresovir has a first-mover advantage, it faces competition from other approved monoclonal antibodies for RSV, such as nirsevimab and clesrovimab, which have already captured market share [8].
爱科百发三冲IPO背后:两年半累计亏损达5.71亿元,主要产品依赖授权引进,核心产品仍在突围|创新药观察
Hua Xia Shi Bao·2025-09-29 13:01