BioCryst Completes Sale of European ORLADEYO® (berotralstat) Business

Core Insights - BioCryst Pharmaceuticals has completed the sale of its European ORLADEYO business to Neopharmed Gentili for $250 million, with potential future milestones of up to $14 million [1][8] - The transaction allows BioCryst to focus on its core U.S. market, significantly improving its operating margin and cash flow generation [2][8] - Neopharmed Gentili will manage the commercialization of ORLADEYO in Europe, retaining the existing European commercial organization built by BioCryst [8] Transaction Details - The sale price of $250 million reflects a multiple of approximately 5.4 times sales over the last twelve months ending June 2025 [8] - BioCryst intends to use the proceeds to retire a $199 million Pharmakon term loan, resulting in a cleaner balance sheet for future strategic activities [8] Strategic Advantages - The divestiture of the European business, which was approximately breakeven on a direct basis, provides an immediate improvement to BioCryst's operating margin [8] - The transaction enhances BioCryst's strategic optionality and positions the company to reach the upper half of its 2025 revenue guidance range of $580 million to $600 million, even without European revenue [2][8]