鞍石生物科创板“赶考记”：单药扛营收、商誉压顶，IPO能否解资金困局｜创新药观察

Core Viewpoint - Ansh Biotechnology is facing significant financial challenges despite rapid revenue growth from its core product, Beruatinib, which has been listed and included in the medical insurance catalog. The company is heavily reliant on external financing to sustain operations due to ongoing losses and high cash flow pressure [2][3][9]. Financial Performance - The company reported a revenue of 12.96 million yuan in 2023, projected to increase to 71.66 million yuan in 2024, and 64.04 million yuan in Q1 2025. However, net losses have been substantial, with figures of -1.64 billion yuan, -2.83 billion yuan, -4.79 billion yuan, and -916.53 million yuan for the respective periods [3][4]. - Cumulative losses reached 7.82 billion yuan by the end of Q1 2025, indicating a worsening financial situation [5]. Cost Structure - Research and development expenses have surged from 145 million yuan in 2022 to 326 million yuan in 2024, with Q1 2025 expenses at 76.64 million yuan. Sales expenses also increased dramatically, from 3.61 million yuan in 2022 to 102 million yuan in 2024 [5][8]. - The R&D expense ratio was extraordinarily high at 1418.89% in 2023 and 455.18% in 2024, while sales expense ratios were 350.47% and 141.74% respectively, indicating severe cost pressures [5][8]. Cash Flow and Financing - Operating cash flow has consistently been negative, with figures of -1.66 billion yuan, -2.94 billion yuan, -3.56 billion yuan, and -740 million yuan over the reporting periods, necessitating reliance on external financing [7][9]. - The company completed a 900 million yuan Series B financing, with a post-financing valuation of 5.25 billion yuan, highlighting the need for continued external funding to maintain operations [9]. Market Strategy and Risks - The company adopted a "price-for-volume" strategy, significantly reducing the price of Beruatinib from 17,200 yuan to 6,700 yuan, leading to a surge in sales volume but also a decline in gross margin from 84.93% to 80.28% [10][11]. - High inventory levels have emerged, with stock reaching 74.65 million yuan by the end of 2024, indicating potential risks of inventory devaluation and cash flow issues [10][11]. Competitive Landscape - Ansh Biotechnology faces intense competition with five other MET-TKI drugs approved for the same indication, which could impact market share and revenue growth [12]. - The company is heavily reliant on Beruatinib, with no product diversification to mitigate risks associated with market fluctuations and competitive pressures [12]. Goodwill and Financial Health - The company has a significant goodwill of 927 million yuan, accounting for 56.64% of total assets, raising concerns about potential impairment risks that could adversely affect financial performance [12].