Zhi Tong Cai Jing·2025-10-20 02:19Group 1 - The core viewpoint of the article highlights the licensing agreement between Hansoh Pharmaceutical (03692) and Roche for HS-20110 (CDH17ADC), which includes an upfront payment of $80 million and potential milestone payments of up to $1.45 billion, along with product sales sharing [1] - HS-20110 is a potential first-in-class (FIC) product currently undergoing global Phase I clinical trials for the treatment of colorectal cancer and other solid tumors in China and the United States [1] - The report indicates optimism regarding Hansoh Pharmaceutical's milestone revenue normalization and external licensing opportunities, with management raising the annual revenue guidance to a mid-to-high double-digit growth [1] Group 2 - The company is expected to achieve over 10 billion in innovative drug revenue by 2025, with the innovative drug revenue proportion likely to exceed 80% [1] - Milestone and upfront payment revenue is anticipated to exceed 2.2 billion [1] - The early pipeline includes several innovative molecules such as EGFR/cMET ADC and CDH6ADC, which have external licensing opportunities [1] Group 3 - The company is also optimistic about the continued growth of its core product, Amivantamab, in the domestic market, with four approved indications and projected sales exceeding 6 billion by 2025, with a peak single-drug sales potential of 8 billion [2] - Amivantamab in combination with chemotherapy for first-line treatment of NSCLC is expected to receive approval in the second half of the year [2] - The research pipeline includes combinations of Amivantamab with c-Met TKI and EGFR/c-Met bispecific antibodies/ADCs, which are expected to further strengthen the company's leading position in the lung cancer market [2]