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曾一年卖出上千万支的神经生长因子产品退潮,海特生物赴港“输血” 创新药能否突围|创新药观察

Core Viewpoint - Wuhan Haitai Biopharmaceutical Co., Ltd. is facing significant challenges with both revenue and profit declining sharply, highlighting a critical point in its performance deterioration as it prepares for an H-share listing to raise funds for innovation and operational needs [2][12]. Financial Performance - In Q3 2025, the company's revenue was 147 million yuan, a year-on-year decline of 11.74%, while the net profit attributable to shareholders was a loss of 119 million yuan, a staggering drop of over 600% [4][6]. - The cumulative revenue for the first three quarters of 2025 was 422 million yuan, down 6.45% year-on-year, marking a continuation of four years of revenue stagnation and increasing losses [4][6]. - The net profit for the first three quarters of 2025 was a loss of 158 million yuan, with a year-on-year decline of 297.78%, indicating a severe financial strain [6]. Product and Market Challenges - The core product, "Jinlujie," has seen a significant decline in sales, dropping from 12 million units in 2020 to 4.5 million units in the first three quarters of 2025, with its revenue contribution plummeting from over 60% to less than 20% [7][12]. - The company has been adversely affected by policy changes, including the removal of "Jinlujie" from the national medical insurance catalog, which has led to reduced sales and increased competition in the oncology sector [5][12]. R&D and Strategic Focus - Despite financial pressures, the company has maintained its R&D investment, with expenses exceeding 120 million yuan annually, representing over 18% of revenue, which is significantly higher than the industry average [9]. - The R&D strategy has shifted from a broad approach to a more focused one, concentrating resources on oncology and cardiovascular diseases, while reducing the workforce in R&D from 691 to 537 [9][10]. Cash Flow and Financial Health - The company's cash flow situation has deteriorated, with a net cash flow from operating activities turning negative at -76 million yuan in the first three quarters of 2025, a decline of 374.1% year-on-year [10]. - As of September 2025, the company's cash balance was only 170 million yuan, down 59.55% from the beginning of the year, raising concerns about its ability to meet short-term obligations [11]. Future Outlook - The planned H-share listing aims to raise 500 to 800 million HKD to alleviate financial pressures and support R&D efforts, reflecting the broader challenges faced by small to medium-sized pharmaceutical companies in China [2][12].