口服麦角硫因：生物制造、市场应用及未来展望

Core Insights - The article highlights the rising popularity of ergothioneine, particularly in the context of the upcoming Double Eleven shopping festival, with significant sales figures reported for brands promoting anti-aging products [1][2]. Group 1: Scientific Research and Development - Research on ergothioneine has primarily focused on its efficacy, with significant contributions from Chinese scientists, particularly a breakthrough study published in Nature in 2015 that revealed its role in antibiotic synthesis [2][6]. - The discovery of specific transport proteins for ergothioneine has established it as a key molecule related to human health, beyond its antioxidant properties [6][7]. Group 2: Market Growth and Projections - The global market for ergothioneine is projected to grow from approximately $39.59 million in 2023 to $806 million by 2033, reflecting a compound annual growth rate (CAGR) of 36.2% [8]. - The increasing demand for antioxidant and anti-aging ingredients is driving this market growth, alongside advancements in production technology [8]. Group 3: Production Methods - Three main methods for synthesizing ergothioneine have been identified: chemical synthesis, chemical synthesis combined with enzymatic catalysis, and precision fermentation [10][12][13]. - Precision fermentation is viewed as the most promising method for sustainable and cost-effective production, leveraging microorganisms with ergothioneine biosynthesis capabilities [14][15]. Group 4: Applications in Health and Food Industry - Ergothioneine is being explored for use in dietary supplements and health products, with companies like Tetrahedron and Blue California leading the way in industrial applications [18][19]. - Its potential as a natural preservative and antioxidant in food products is also being recognized, with applications in seafood preservation and functional foods [21][23]. Group 5: Regulatory Approvals and Market Entry - Ergothioneine has received regulatory approvals in the EU and the US, allowing its use in various food products and dietary supplements, which has facilitated its market entry [24][25]. - The article notes that while ergothioneine has gained recognition in international markets, its approval process in China is still ongoing, with several applications pending [27][28].