肿瘤治疗2.0时代，创新药竞逐新高地

Core Insights - The approval of PD-1 inhibitors Keytruda and Opdivo a decade ago has significantly transformed cancer treatment, particularly in lung cancer, melanoma, and lymphoma, marking the beginning of the immunotherapy era [1] - As key patents near expiration and biosimilars enter the market, the market share of leading products is under pressure, with Merck's Keytruda sales growth slowing to 8% and BMS's Opdivo experiencing a 1% decline [1] - The oncology market is evolving into a "2.0 era," with companies like Merck and BMS focusing on combination therapies involving PD-1 and ADCs to maintain competitive advantages [1][2] Industry Overview - The global oncology drug market is projected to grow from $168 billion in 2020 to $247 billion by 2024, with a compound annual growth rate (CAGR) of 10.2%, while the ADC market is expected to exceed $35 billion with a CAGR of 41.7% [1] - The shift in market dynamics indicates a move towards a multi-target competition era, emphasizing ADCs and combination therapies [1] Company Strategies - Merck is actively building a "PD-1+ADC" treatment matrix through acquisitions and partnerships, aiming to extend the lifecycle of Keytruda [2] - Recent FDA approvals for combination therapies, such as Keytruda with Padcev for bladder cancer, highlight the potential for these combinations to change clinical practices [3] - BMS has also expanded its combination therapies, with its dual immunotherapy for liver cancer becoming the first approved in China [3] Domestic Innovations - Chinese biotech companies are rapidly advancing in the "PD-1+ADC" space, with companies like Junshi Biosciences reporting promising clinical data for their PD-L1 ADC, HLX43, in non-small cell lung cancer [4] - The industry is moving towards "dual antibodies/multi-antibodies + ADC" strategies, with companies like Rongchang Bio and Pfizer exploring innovative combinations [5] Future Directions - The next generation of IO and ADC therapies is expected to become a focal point for multinational corporations in the oncology sector, with a strong emphasis on business development in China [6] - Companies are increasingly inclined to pursue co-development models as clinical data becomes more robust, indicating a trend towards strategic partnerships in the industry [6]