AbbVie Stock Rebounds After Q3 Dip: Time to Buy, Hold or Sell?

Core Insights - AbbVie reported third-quarter 2025 results, beating estimates for both earnings and sales, with sales increasing by 9.1% year over year, while earnings declined by 38% due to acquisition-related costs [1][9] - The company raised its revenue and EPS guidance for 2025 for the third time this year, supported by strong year-to-date momentum [1] Sales Performance - AbbVie's stock initially declined post-earnings release due to softer sales in oncology drugs and ongoing weakness in the Aesthetics unit, but later recovered and crossed the 50-day moving average [2] - Sales of AbbVie's ex-Humira drugs rose over 20% in Q3, driven by strong performances from Skyrizi and Rinvoq, which generated combined sales of $18.5 billion in the first nine months of 2025 [24][4] Drug Portfolio - AbbVie successfully navigated the loss of exclusivity for Humira by launching new immunology drugs, Skyrizi and Rinvoq, which are expected to support top-line growth in the coming years [3][5] - Skyrizi is annualizing at almost $18 billion, while Rinvoq is at over $8 billion, with expectations to exceed combined sales of $25 billion in 2025 and $31 billion by 2027 [5] Oncology and Neuroscience Contributions - The oncology segment generated combined revenues of $5.0 billion in the first nine months of 2025, up 2.7% year over year, driven by higher sales of Venclexta and contributions from new drugs [7] - AbbVie's neuroscience portfolio saw a 20.3% increase in sales to nearly $7.8 billion, supported by higher sales of Botox Therapeutic and newer migraine drugs [8] Challenges and Adjustments - AbbVie is experiencing declining sales in its Aesthetics unit, with global sales down 0.6% in 2024 and 7.4% in the first nine months of 2025, attributed to macroeconomic challenges and low consumer sentiment [13][14] - The company lowered its expectations for the Aesthetics business from $5.1 billion to $4.9 billion due to greater-than-expected market softness [15] Financial Outlook - AbbVie stock has risen 31.6% year-to-date, outperforming the industry and S&P 500 [16] - The stock is reasonably priced with a forward P/E ratio of 16.74, lower than the industry average of 16.81 [19] - Despite recent estimate declines, AbbVie expects to return to mid-single-digit revenue growth in 2025, driven by robust performances from Skyrizi and Rinvoq [25][26]