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Core Viewpoint - The article discusses a breakthrough in hydrogel technology developed by researchers at East China University of Science and Technology, which features a self-repairing gel that can revolutionize precision medicine through its unique ion-responsive properties [1][3][8]. Group 1: Scientific Discovery - The gel was initially thought to be a failed experiment when it disintegrated but surprisingly reformed itself the next day, leading to the discovery of its self-repairing capabilities [1][4]. - The research team identified the Hofmeister effect as the key scientific principle behind the gel's behavior, which involves specific ions affecting the arrangement of water molecules and thus the solubility of biological macromolecules [4][6]. - This discovery combines a century-old theory with modern dynamic self-assembly techniques, resulting in a supramolecular hydrogel capable of transitioning between gel and liquid states based on ionic conditions [6][8]. Group 2: Medical Applications - The ion-responsive gel addresses significant issues in traditional drug delivery systems, which often result in ineffective treatment due to either premature drug release or inability to deliver large molecules [8][11]. - The gel's mechanism allows for precise drug delivery by disintegrating in response to ion concentration changes, ensuring that medication is released directly at the target site [9][11]. - Its biocompatibility is enhanced compared to traditional covalently cross-linked hydrogels, allowing for minimally invasive treatments and easy clearance from the body post-application [11][12]. Group 3: Market Potential - The hydrogel technology has broader applications beyond drug delivery, including potential uses as ion sensors for monitoring specific ion concentrations in the body, which could lead to early disease detection [12][15]. - The Chinese hydrogel market is projected to reach approximately $4 billion by 2024, with expectations for further growth as smart materials become more prevalent [15][17]. - The research has garnered international attention, with publications in prestigious journals, indicating a strong interest in the technology within the academic and commercial sectors [15][17].