玛巴洛沙韦已出现耐药情况？罗氏回应

Core Viewpoint - The rise in flu cases has led to reports of drug resistance to commonly used antiviral medications, Oseltamivir and Baloxavir, prompting discussions on their efficacy and safety [2] Group 1: Drug Efficacy and Comparison - Roche claims that Baloxavir, when taken as a single course, provides similar symptom relief duration compared to Oseltamivir, with superior values and significantly shorter viral shedding time [2] - Baloxavir has a lower overall adverse event rate and drug-related adverse event rate compared to Oseltamivir, with better gastrointestinal tolerance [2] Group 2: Recommendations and Guidelines - Global flu prevention and treatment guidelines, including those in China, recommend Baloxavir for the treatment of both influenza A and B based on rigorous drug risk-benefit assessments [2] - Roche emphasizes the importance of considering both efficacy and safety in drug comparisons, warning against focusing solely on specific adverse reactions which may lead to public misunderstanding [2]