解码生命基石，巨子生物驱动生物科技产业跃迁

Core Insights - The article highlights the significant innovation achieved by the Chinese biotechnology company, Juzhibio, in the field of recombinant collagen, particularly recombinant type IV collagen, overcoming technical bottlenecks through synthetic biology advantages [1][2][3]. Group 1: Technological Breakthroughs - Juzhibio has made substantial progress in the production of recombinant type IV collagen, achieving high activity and purity in large-scale production through advancements in expression systems, production processes, and efficacy validation [1][2]. - The company utilized Pichia pastoris as an expression host, achieving a secretion yield of approximately 25.1 g/L with a purity of over 90%, addressing the economic feasibility of large-scale production [3]. - Juzhibio conducted the first systematic scientific validation in China regarding the mechanism of recombinant type IV collagen's effect on skin basement membrane integrity, confirming its ability to promote the synthesis and expression of key substances in the basement membrane [4]. Group 2: Market Applications - The core technology in recombinant type IV collagen has been effectively applied to Juzhibio's consumer brand "Kefumei," resulting in successful market products such as the "Kefumei Collagen Stick 2.0," which addresses modern consumer skincare needs [6]. - Juzhibio has also developed a specialized product line, "Kefumei Frame Domain Repair Series," targeting post-aesthetic care, thus tapping into a high-growth market segment [7]. Group 3: Industry Leadership - Juzhibio has established a robust patent portfolio with 186 patents and applications, positioning itself as a leader in the global intellectual property landscape within the biotechnology sector [9]. - The company actively participates in the formulation of industry standards, having contributed to multiple standards related to recombinant collagen, thereby promoting scientific and transparent development in the industry [9]. - Juzhibio has expanded its global market presence, successfully entering markets in Canada, the USA, Japan, South Korea, Singapore, and Thailand, showcasing the capability of Chinese enterprises in the forefront of life sciences [10].