Stock Market Today: S&P 500, Dow Jones Futures Down As Santa Rally Hopes Fade—Investors Await Initial Jobless Claims Report - SPDR S&P 500 (ARCA:SPY)

Market Overview - U.S. stock futures are down on New Year's Eve, with markets closing lower on Tuesday, diminishing hopes for a year-end Santa Claus rally [1] - The Dow Jones, S&P 500, Nasdaq 100, and Russell 2000 all experienced declines in premarket trading [4] - The 10-year Treasury bond yielded 4.12%, while the two-year bond was at 3.44%, with an 82.8% likelihood of the Federal Reserve maintaining current interest rates in January [3] Stocks in Focus - iSpecimen Inc. (NASDAQ:ISPC) shares rose 36.95% pre-market after announcing a $5.5 million private placement [6] - Anghami Inc. (NASDAQ:ANGH) shares increased by 56% following a report of a 97% year-over-year revenue surge [6] - Urgent.ly Inc. (NASDAQ:ULY) saw a significant rise of 52.49% on Tuesday and an additional 26.81% pre-market on Wednesday after adjourning its annual stockholder meeting [6] - Vanda Pharmaceuticals Inc. (NASDAQ:VNDA) shares climbed 19.06% pre-market after FDA approval of its new drug for motion-induced vomiting [13] - Core AI Holdings Inc. (NASDAQ:CHAI) shares increased by 2.78% after announcing a divestiture agreement, despite a previous drop of 5.75% [13] Economic Indicators - Investors are anticipating the Initial Jobless Claims report set to be released before market opening [2][11]