21专访丨东阳光药首席科学家林凯:不盲目跟风,做更具创新性的事
2 1 Shi Ji Jing Ji Bao Dao·2026-01-05 23:18

Core Insights - The Chinese innovative pharmaceutical industry is transitioning from scale expansion to value enhancement, facing challenges such as market saturation and homogeneous competition [1] - Local pharmaceutical companies need to break through these challenges to achieve high-quality development by focusing on unmet clinical needs and building core competitiveness through differentiated strategies [2] Group 1: Innovation Strategy - The company emphasizes a balanced strategy of "walking on two legs," focusing on both clinically validated traditional targets for stable revenue and innovative products with high added value [4] - Current research and development efforts are concentrated in three core areas: infectious diseases, metabolic diseases, and oncology, with a focus on unmet clinical needs [5][6] Group 2: Clinical Development - The company is advancing the clinical trial of HEC585, an innovative drug for idiopathic pulmonary fibrosis (IPF), which has shown promising results in Phase II trials, significantly outperforming competitors [6][7] - The drug's mechanism involves inhibiting TNF-α and TGF-β1, providing a comprehensive approach to fibrosis treatment, with plans for international collaboration for broader market access [7] Group 3: AI in Drug Development - The company has developed an AI drug discovery platform that leverages over 20 years of laboratory data, enhancing the efficiency of drug development processes [8] - AI applications have significantly reduced the time required for drug screening and development, exemplified by a project that achieved a 50% reduction in development time [9] Group 4: International Expansion - The trend of Chinese innovative drugs going global is increasing, driven by improved R&D capabilities and the need to cover costs for rare disease treatments through international markets [12] - The company has initiated partnerships for overseas commercialization, including a licensing deal with Apollo Therapeutics for a dual-target drug [13][14] Group 5: Market Strategy - The company aims to balance clinical and market needs by focusing on high-demand areas with limited treatment options, while also considering international market opportunities [17] - The strategy includes leveraging existing strengths in infection and metabolism while exploring differentiated targets in oncology, ensuring alignment with both domestic and international market demands [17]

GDHEC CO.,LTD-21专访丨东阳光药首席科学家林凯:不盲目跟风,做更具创新性的事 - Reportify