Nimbus与礼来达成合作 联合开发新型口服减肥药

Core Insights - Nimbus Therapeutics has signed a multi-year research and licensing agreement with Eli Lilly to develop AI-driven oral therapies for obesity and other metabolic diseases [1][3] - The agreement includes an upfront payment of $55 million from Eli Lilly to Nimbus, with potential milestone payments up to $1.3 billion if the drug is successfully developed and approved [1][3] - The trend of integrating AI in drug discovery aligns with the FDA's recent push to reduce animal testing [1][3] Company Developments - Nimbus previously licensed an AI-designed compound to Takeda Pharmaceutical in 2022, with a total deal value of up to $6 billion, which is currently undergoing late-stage clinical trials [1][3] - This collaboration marks the second partnership between Nimbus and Eli Lilly, following their previous agreement to develop an oral drug for cardiac metabolic diseases [4][5] - Nimbus, based in Boston, focuses on oral drug development across various fields, including cancer, inflammatory diseases, and metabolic diseases [4][5] Industry Trends - Global pharmaceutical companies are competing to develop oral weight-loss medications as alternatives to injectable drugs like Novo Nordisk's semaglutide (Wegovy) and Eli Lilly's tirzepatide (Zepbound) [2][4] - The weight-loss drug market is projected to exceed $150 billion in annual revenue by the early 2030s [2][4] - The collaboration aims to leverage Nimbus's AI technology for drug candidate selection while Eli Lilly contributes its expertise in metabolic diseases [2][4]