Zhi Tong Cai Jing·2026-01-08 13:31Group 1 - The core issue is the severe shortage of the antiviral drug Tamiflu (oseltamivir) in the U.S. and globally, particularly in cold regions facing high flu activity [1][2] - The American Society of Health-System Pharmacists (ASHP) is assessing the shortage, noting that areas with historically high flu activity are experiencing the most severe supply issues [2] - The CDC reported that hospital visits due to flu-like symptoms have reached the highest level since the 1997-98 flu season, with a notable increase in cases attributed to a new variant of the flu virus [3] Group 2 - Tamiflu is a neuraminidase inhibitor that reduces the spread of the flu virus and is most effective when taken within 48 hours of symptom onset [4] - The FDA has approved Tamiflu for use in individuals aged 2 weeks and older, emphasizing early treatment for high-risk populations [5] - Other antiviral medications listed by the CDC include zanamivir, peramivir, and baloxavir, which have different mechanisms of action [5]