“减肥神药”停药后如何？两年内恢复原“胖”

Core Insights - A recent study published in the British Medical Journal (BMJ) indicates that patients who stop using anti-obesity medications will regain their original weight within two years, losing the associated health benefits such as improved heart health, cholesterol levels, and blood pressure [1][2] - The analysis, which included data from over 9,000 participants, highlights the rapid weight rebound and deterioration of health indicators occurring even before full weight restoration [1][2] Group 1: Weight Rebound and Health Implications - The study analyzed 37 research studies and found that participants lost an average of 8.3 kg during treatment but would regain their original weight in less than 21 months after stopping the medication [2] - Beneficial effects on heart health, cholesterol, and blood pressure are expected to diminish within 18 months post-medication [2] - The research emphasizes that weight loss through medication is faster but leads to quicker rebound compared to behavioral weight loss programs [2] Group 2: Long-term Intervention Necessity - Experts stress the need for ongoing interventions to maintain weight loss results, especially as millions may stop using these medications in the coming years [3] - The study's findings align with emerging views on the limitations and advantages of such medications [2][3] Group 3: Nutritional Risks and Muscle Loss - A separate study published in Obesity Reviews indicates that users of weight loss medications may face nutritional deficiencies and muscle loss due to inadequate dietary guidance [4] - Up to 40% of the weight lost may consist of lean body mass, including muscle, highlighting the risks of unmonitored medication use [4] - The lack of nutritional support for users who purchase medications privately raises concerns about replacing one health issue with another [4]