博锐生物闯关港交所，已有8款产品商业化

Core Viewpoint - Zhejiang Haizheng Pharmaceutical Co., Ltd. (referred to as "Haizheng Pharmaceutical") announced that its subsidiary Zhejiang Borui Biopharmaceutical Co., Ltd. (referred to as "Borui Biopharma") has submitted an application for an H-share initial public offering (IPO) to the Hong Kong Stock Exchange, aiming for a listing on the main board [1]. Company Overview - Borui Biopharma focuses on immunotherapy and has integrated capabilities in research, production, and sales. Its history dates back to the biopharmaceutical division of Haizheng Pharmaceutical and was restructured into a limited liability company in January 2019 [2]. - Borui Biopharma has established a portfolio of immunotherapy products, including eight commercialized products such as the first and only approved CD20-targeting innovative drug in China, and several innovative ADC pipelines based on next-generation technology platforms [2]. Financial Performance - Borui Biopharma has shown stable revenue growth, with reported revenues of 1.257 billion yuan, 1.623 billion yuan, and 1.379 billion yuan for the years 2023, 2024, and the first nine months of 2025, respectively. The profit attributable to equity shareholders increased from 19.05 million yuan in 2023 to 122 million yuan in the first nine months of 2025 [3]. - However, the gross profit margin has been declining, with figures of 82.2%, 79.2%, and 74.4% for the years 2023, 2024, and the first nine months of 2025, respectively, reflecting a cumulative decrease of 7.8 percentage points [3]. Market Challenges - Borui Biopharma faces multiple challenges in the biopharmaceutical industry, including ongoing pressure from volume-based procurement policies and competition from other companies in the autoimmune and oncology sectors, which may lead to reduced profit margins [4]. - The company has a high customer concentration risk, with over 68% of its revenue coming from its top five clients, which amplifies operational uncertainties [4]. - The complexity of biopharmaceutical production processes poses quality control risks, and the long development cycles and high failure rates of innovative drugs present ongoing challenges to its sustainability [4]. IPO Process - Borui Biopharma's IPO process requires approvals from the China Securities Regulatory Commission, the Hong Kong Securities and Futures Commission, and the Stock Exchange, indicating that there are uncertainties in the timeline and outcome of the IPO [5].