新方法可“改造升级”，T细胞显著提升清除癌细胞能力

Group 1 - The research team from the Chinese Academy of Sciences has developed a "histidine scanning method" that can quickly locate key sites on T cell receptors (TCR) responsible for recognizing cancer cells and initiating clearance programs [1] - The modified TCR molecules act as highly sensitive enhanced "security scanners," significantly improving T cells' ability to eliminate cancer cells [1] - This method does not rely on the three-dimensional structural information of TCR molecules, allowing for simultaneous modification of multiple key sites to enhance the ability of TCRs to capture cancer cells [1] Group 2 - The modified T cells exhibit higher activation levels and stronger killing power, with the ability to accurately distinguish between cancerous and healthy cells, thus avoiding collateral damage [1] - The research has shown significant efficacy in animal models, providing a new approach for developing the next generation of efficient and precise cancer immunotherapies [1] - Related A-share concept stocks include Hanyu Pharmaceutical and New Source [2]