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MindRank Announces First Patient Dosed in Phase III Trial of AI-Designed Oral GLP-1 Receptor Agonist MDR-001
Globenewswire· 2026-02-26 02:22
Core Insights - MindRank has initiated the Phase III clinical trial for MDR-001, an AI-designed oral GLP-1 receptor agonist aimed at treating obesity and type 2 diabetes in China [1][2] - The trial, named MOBILE, will involve approximately 750 patients across 50 clinical centers, assessing the long-term efficacy and safety of MDR-001 [2] - MDR-001 has shown promising results in a Phase IIb trial, demonstrating clinically meaningful efficacy and favorable tolerability [3] Company Overview - MindRank is a clinical-stage biotechnology company that leverages AI for drug discovery, focusing on "hard-to-drug" targets to enhance the efficiency and success rate of new drug development [9] - The company utilizes its proprietary AI platform, Molecule Pro™, which integrates various scientific disciplines to optimize drug discovery processes [7][9] Technology and Innovation - The Molecule Pro™ platform employs advanced AI techniques, including deep learning and generative AI, to facilitate drug discovery and optimize lead compounds [7][8] - The platform's capabilities include predicting drug safety and optimizing molecular design to improve the chances of successful drug development [8] Development Milestones - The development of MDR-001 progressed from project initiation to U.S. IND clearance in 19 months and reached Phase III within approximately 4.5 years [4] - The dosing of the first patient in Phase III is considered a significant milestone for both MDR-001 and AI-driven drug development [6]
Paul Mueller Company and Springfield Public Schools Announce Welding & Grinding Youth Apprenticeship Partnership
Globenewswire· 2026-02-26 01:55
Core Insights - Paul Mueller Company and Springfield Public Schools have launched a Welding and Grinding Registered Youth Apprenticeship partnership, marking a significant advancement in workforce development for advanced manufacturing in Missouri [1][9] - This initiative is the only stainless welding and grinding pathway in Missouri, creating a direct link between classroom education and paid industry experience [2][9] Company Overview - Paul Mueller Company is recognized as one of the largest and most innovative stainless steel manufacturers globally, with over 85 years of experience in manufacturing [2] - The company specializes in designing and manufacturing stainless steel processing equipment and heat transfer solutions for various markets, including food, beverage, dairy, pharmaceutical, chemical, nuclear, and industrial sectors [6] Apprenticeship Program Details - The apprenticeship program allows students aged 17 and above to earn up to $25 per hour while gaining hands-on experience in stainless steel welding and grinding, along with earning educational credits [4] - The program follows a nationally recognized Registered Apprenticeship model, emphasizing paid employment, structured on-the-job learning, industry-aligned training, and portable credentials [4] Community Impact - The partnership aims to create meaningful opportunities for students and strengthen the skilled workforce in southwest Missouri, reflecting a commitment to community investment and operational excellence [5] - This initiative is expected to build a sustainable talent pipeline that supports both student success and regional economic strength [5]
Draganfly Announces Pricing of US$50.0 Million Registered Direct Offering
Globenewswire· 2026-02-26 01:50
Core Viewpoint - Draganfly Inc. has announced a registered direct offering of 7,150,000 common shares at a price of US$7.00, aiming for gross proceeds of approximately US$50.0 million before expenses [1]. Group 1: Offering Details - The offering is being led by Maxim Group LLC, with Raymond James Ltd. and Ladenburg Thalmann & Co. Inc. as co-placement agents [2]. - The expected closing date for the offering is around February 27, 2026, pending customary closing conditions [3]. - The offering is subject to regulatory approvals from the Canadian Securities Exchange and notification to the Nasdaq Stock Market [4]. Group 2: Use of Proceeds - Draganfly intends to utilize the net proceeds for general corporate purposes, including funding new product capabilities, growth initiatives, working capital, and ongoing development and marketing of core products [3]. Group 3: Regulatory Compliance - The offering is made under an effective shelf registration statement filed with the U.S. Securities and Exchange Commission and the Company's Canadian short form base shelf prospectus [5]. - A prospectus supplement will be filed with relevant securities commissions in Canada and the SEC in the U.S. [6]. Group 4: Company Overview - Draganfly Inc. is a pioneer in drone solutions, AI-driven software, and robotics, with over 25 years of innovation in various sectors including public safety, agriculture, and industrial inspections [8].
TRG Latin America Acquisitions Corp. Announces Pricing of $200 Million Initial Public Offering
Globenewswire· 2026-02-26 01:27
Company Overview - TRG Latin America Acquisitions Corp. is a blank check company incorporated in the Cayman Islands, formed to effect a merger, amalgamation, share exchange, asset acquisition, share purchase, reorganization, or similar business combination with one or more businesses [4] - The company intends to leverage the expertise of its management team, particularly focusing on identifying a target business that can benefit from the experience of its CEO and Chairman Nicolas S. Rohatyn and CFO Miguel A. Gutierrez [5] Initial Public Offering (IPO) Details - The company has priced its initial public offering at $10.00 per unit, with a total of 20,000,000 units being offered [1] - The units will be listed on the Nasdaq Stock Exchange under the ticker symbol "TRGSU" starting February 26, 2026, and will consist of one Class A ordinary share and one right entitling the holder to receive one-tenth of one Class A ordinary share upon the completion of a business combination [1] - The offering includes a 45-day option for the underwriter, Santander, to purchase up to an additional 3,000,000 units at the IPO price to cover over-allotments [2] - The offering is expected to close on February 27, 2026, subject to customary closing conditions [3] Management and Board Members - The management team includes Nicolas S. Rohatyn as CEO and Chairman, and Miguel A. Gutierrez as CFO, both of whom are co-founders and partners at The Rohatyn Group [5] - The board of directors will include Miguel Kiguel, Daniel Gerold, and Thomas Wolf [6]
Enerflex Ltd. Announces Fourth Quarter 2025 Financial and Operational Results, Agreement to Divest Non-Core Business and Provides Preliminary Outlook for 2026
Globenewswire· 2026-02-26 01:21
Core Insights - Enerflex reported adjusted EBITDA of $123 million and record free cash flow of $141 million for Q4/25, with a reduction in net debt to $501 million, approximately 1.0x trailing twelve-month adjusted EBITDA [1][12][5] - The company signed an agreement to divest its operations in the Asia Pacific region, aiming to optimize and simplify its business [1][8] - Capital expenditures for 2026 are targeted between $175 million and $195 million, including $90 million to $100 million for growth opportunities [1][18] Financial Overview - Revenue for Q4/25 was $627 million, an increase from $561 million in Q4/24 but a decrease from $777 million in Q3/25, primarily due to project timing [5] - Gross margin before depreciation and amortization was $177 million, or 28% of revenue, compared to 31% in Q4/24 and 27% in Q3/25 [5][11] - Selling, general and administrative expenses (SG&A) decreased to $83 million from $92 million in Q4/24, driven by cost-saving initiatives [5][11] Operational Highlights - The Engineered Systems (ES) backlog was $1.1 billion, providing strong visibility into future revenue generation [1][8] - ES bookings in Q4/25 were $377 million, up from $301 million in Q4/24, indicating a healthy book-to-bill ratio of 1.1x [8][13] - The company continues to expand its U.S. contract compression business, with utilization stable at 94% across a fleet of approximately 483,000 horsepower [8][9] Shareholder Returns - The Board of Directors increased the quarterly dividend by 13% to CAD$0.0425 per share, payable on March 25, 2026 [8][22] - Enerflex repurchased 102,800 common shares at an average price of CAD$15.10 per share during Q4/25, totaling 2,779,000 shares repurchased since the start of its normal course issuer bid [8][21] Outlook - The preliminary outlook for 2026 indicates steady demand across business lines, supported by the highly contracted Energy Infrastructure product line, expected to generate approximately $1.3 billion in revenue [16][17] - The company aims to leverage its position in core operating countries to capitalize on expected increases in demand for its solutions [19][20]
Palvella Therapeutics Announces Pricing of Upsized Public Offering
Globenewswire· 2026-02-26 00:57
Group 1 - Palvella Therapeutics, Inc. announced the pricing of its upsized public offering of 1,600,000 shares at $125.00 per share, with expected gross proceeds of $200 million [1] - The offering includes a 30-day option for underwriters to purchase an additional 240,000 shares [1] - The offering is expected to close on or about February 27, 2026, subject to customary closing conditions [1] Group 2 - The net proceeds from the offering will be used to support the development of programs including QTORIN rapamycin and QTORIN pitavastatin, as well as for working capital and general corporate purposes [3] - The offering is made pursuant to a shelf registration statement declared effective by the SEC on January 29, 2026 [4] Group 3 - Palvella is focused on developing therapies for serious, rare skin diseases and vascular malformations, with a pipeline based on its patented QTORIN™ platform [6] - The lead product candidate, QTORIN™ rapamycin, is being developed for microcystic lymphatic malformations and other conditions, while QTORIN™ pitavastatin is for the treatment of disseminated superficial actinic porokeratosis [6][7]
APEX Tech Acquisition Inc. Prices $100 Million Initial Public Offering
Globenewswire· 2026-02-26 00:41
Group 1 - APEX Tech Acquisition Inc. has announced the pricing of its initial public offering (IPO) of 10,000,000 units at an offering price of $10.00 per unit, with each unit consisting of one ordinary share and one right to receive one-fourth (1/4) of one ordinary share upon the consummation of an initial business combination [1] - The units are expected to trade on The New York Stock Exchange (NYSE) under the ticker symbol "TRADU" beginning February 26, 2026, with the IPO expected to close on February 27, 2026, subject to customary closing conditions [1] - Once the securities comprising the units begin separate trading, the ordinary shares and the rights are expected to be traded on NYSE under the symbols "TRAD" and "TRADR," respectively [1] Group 2 - A.G.P./Alliance Global Partners is acting as the sole book-running manager for the offering and has been granted a 45-day option to purchase up to 1,500,000 units at the initial public offering price to cover over-allotments [2] - A registration statement on Form S-1 relating to the securities was previously filed with the Securities and Exchange Commission (SEC) and declared effective on February 25, 2026 [3] Group 3 - APEX Tech Acquisition Inc. is a blank check company incorporated in the Cayman Islands with limited liability, aimed at effecting a merger, share exchange, asset acquisition, share purchase, reorganization, or similar business combination with one or more businesses or entities [5] - The company intends to conduct a search for target businesses without being limited to a particular industry [5]
Northland Power Reports Fourth Quarter 2025 Results and 2026 Financial Outlook
Globenewswire· 2026-02-26 00:10
Core Insights - Northland Power Inc. reported financial results for the year ended December 31, 2025, highlighting a strategic focus on maximizing long-term shareholder value through a five-year plan and growth initiatives in Canada and Europe [3][6][39]. Financial Performance - In Q4 2025, Northland achieved an Adjusted EBITDA of $1.25 billion, aligning with financial guidance, and Free Cash Flow of $1.46 per share, exceeding expectations [6][12]. - Full-year 2025 revenue from energy sales increased to $2.43 billion from $2.35 billion in 2024, while net income decreased to a loss of $108 million due to a significant impairment expense [12][30]. - Q4 2025 revenue from energy sales was $723 million, up from $572 million in Q4 2024, with net income rising to $290 million from $150 million in the same quarter of the previous year [12][30]. Operational Highlights - The operating fleet availability in Q4 2025 was 96%, with offshore wind assets in Germany achieving record production [4][6]. - Northland is advancing two major offshore wind projects: the 1.0 GW Hai Long project, with 37 out of 73 turbines installed, and the 1.1 GW Baltic Power project, which is on track for commercial operations in the second half of 2026 [7][8][39]. Strategic Developments - A new global strategy was introduced, targeting a doubling of gross operating capacity to 7 GW by 2030, with a focus on cost efficiency and high-quality opportunities [6][8]. - Northland expanded its battery energy storage system pipeline with two late-stage pre-construction projects in Poland, totaling 300 MW / 1.2 GWh [6][8]. Future Outlook - For 2026, Northland expects Adjusted EBITDA to be between $1.45 billion and $1.65 billion, with Free Cash Flow projected at $1.05 to $1.25 per share [41][42]. - The anticipated contributions from the Hai Long and Baltic Power projects are expected to enhance revenue generation, with Hai Long projected to reach commercial operations in 2027 [40][41].
PITAKA Debuts Aaron Button, Turning the Galaxy S26 Case Into a Programmable Control Interface
Globenewswire· 2026-02-26 00:00
Three programmable buttons turn the phone case into a personal control hub—launch apps, trigger smart home routines, or control connected devices, all with a single press. HONG KONG, Feb. 25, 2026 (GLOBE NEWSWIRE) -- PITAKA today announced the launch of Aaron Button, a built-in three-button shortcut system that transforms a phone case from a passive accessory into a personal efficiency hub. Designed to extend smartphone functionality beyond the touchscreen, Aaron Button enables users to launch apps, trigger ...
PITAKA Turns the Galaxy S26 Case Into a Programmable Control Hub With Aaron Button
Globenewswire· 2026-02-26 00:00
HONG KONG, Feb. 25, 2026 (GLOBE NEWSWIRE) -- PITAKA today introduces its Galaxy S26 case lineup featuring the Aaron Button, a built-in three-button shortcut system that transforms a traditional phone case into an intelligent hardware interface. Designed for productivity and customization, Aaron Button allows users to assign programmable shortcuts to physical buttons integrated into the case. With a single press, users can launch apps, trigger smart home routines, activate navigation routes, start recording ...